Inductively coupled plasma mass standard addition calibration

In isotope dilution inductively coupled plasma-mass spectrometry (ID-ICP-MS) the spike, the unspiked and a spiked sample are measured by ICP-MS in order to determine the isotope ratio. Using this technique, more precise and accurate results can be obtained than by using a calibration graph or by standard addition. This is due to elimination of various systematic errors. Isotopes behave identically in most chemical and physical processes. Signal suppression and enhancement due to the matrix in ICP-MS affects both isotopes equally. The same holds for most long-term instrumental fluctuations and drift. Accuracy and precision obtained with ID-ICP-QMS are better than with other ICP-QMS calibration... 

Concentration of the elements Mn, Fe, Cr, Ni, Co, As, Cd, Pb, Zn and Cu in water and plant samples were measured by inductively coupled plasma mass spectrometry (ICP-MS) (ELAN 5000, Perkin-Elmer). The instrument was calibrated by external standards of multi-element solutions for a range of 1-10 p-g/kg for water samples and 0.5-20 (xg/kg for plant material. Digested plant samples were diluted accordingly. Matrix effects and spectral interference were compensated by addition of internal standards ( Rh and Th). 

O Connor, C., Sharp, B.L., and Evans, P. (2006) On-line additions of aqueous standards for calibration of laser ablation inductively coupled plasma mass spectrometry theory and comparison of wet and dry plasma conditions./. Anal. At. Spectrom., 21, 556-565. 

Leach,J.J., Allen, L. A., Aeschliman, D. B., and Houk, R. S. (1999). Calibration of laser ablation inductively coupled plasma mass spectrometry using standard additions with dried solution aerosols. Anal. Chem. 71(2), 440. 

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