Indoramine

In general, activation of alpha-1 adrenergic receptors causes a contraction of smooth muscle and of blood vessels, pilomotor muscles, dilator pupillae, vas deferens, nictitating membrane, splenic capsule, and sphincters of the intestine and urinary bladder and of the bile duct. An exception is the relaxation of the smooth muscle of the intestine. Prazosin [19216-56-9] indoramin [26844-12-2] and WB-4101 are relatively selective antagonists of these receptors. 

Benzamido-1-[2-(3-indolyl)ethyl ] pyridinium bromide Indoramin Benzene... 

Ethionamide Ethoheptazine Ethyl biscoumacetate Etiroxate Fenoxazoline Flurbiprofen Indobufen Indoramin Isocarboxazid Lofexidine Methotrexate Methyidopate Methylphenobarbital Nadoxolol Naphazoline Petindopril Phcnobarbital Propiverine Protionamide Proxazole Pyridoxine Retinol Thiamphenicol Tolazoline Tribenoside ethanolamine... 

QH7N 120-72-9) see Indalpine Indoramin Tinazoline hydrochloride Trandolapril indole-3-carbonyl chloride (C H ClNO 59496-25-2) see Tropisetron indole-3-carboxylic acid... 

C2CI2O2 79-37-8) see Cefuroxime Diclofenae Dorzolamide Fexofenadine hydroehloride Granisetron Gusperimus trihydrochloride Indoramin Maprotiline Micinicate Ritonavir Saquinavir Sumatriptan Tacrolimus Tirofiban hydrochloride Tropisetron Viminol... 

Imidazolone synthesis, 291 Imidoline, 259 Imipramine, 420 Indapamide, 349 Indazole synthesis, 350 Indoles, as starting material for benzodiazepines, 405 Indomethacin, 345 Indoramin, 344 Incfoxoie, 254, 340 Inflammation, 63 Influenza A, 18 Inhibition,... 

Eor preventive treatments, the adverse effects of the beta blockers are classical for this class bradycardia, bronchospasm, hypotension, nightmares and depression. Indoramine induces neuropsychiatric effects (sedation, asthenia) and cardiovascular disorders (hypotension). Eluanarizine is strictly contraindicated in patients with Parkinsonism and depression. 

The peripheral receptors activated by noradrenaline fall into at least two classes, a-receptors and /3-receptors, which differ in their function and in their response to drugs. The a-receptors cause constriction of blood vessels and compounds used to block them include indoramin (216), prazosin (217) and phentolamine (218). Another imidazoline, tolazoline (2-benzyl-2-imidazoline), is a useful vasodilator but is unsuitable for the treatment of hypertension since it stimulates the heart. Other drugs described as peripheral vasodilators are diazoxide (219), which is related to the thiazide diuretics, hydralazine (220) which also depresses the CNS, hydracarbazine (221) and minoxidil (222). The /3-receptors control the action of adrenaline on the heart (among other effects) and the agents that block them are mostly nonheterocyclic aromatic compounds with aminoethanol or 3-amino-2-hydroxypropoxy side-chains. They have proved effective in the treatment of hypertension. One heterocyclic compound of this class, timolol (223), is in use. 

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