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Cat nictitating membrane

Cat nictitating membrane approximate dose (mg/kg, s.c.) causing the coverage shown. Figures in italics represent interpolated data... [Pg.153]

Certain aromatic guanidines (and biguanides) are known to cause a reflex fall of blood pressure and heart rate by an action on receptors in the heart [288]. However, there have been no reports of arylguanidines exhibiting activity at sympathetic nerve endings. o-Bromophenylguanidine (LXXIV) does not affect cat nictitating membranes [239]. [Pg.170]

In anaesthetized cats, the tone of the nictitating membranes may be recorded with a writing lever or strain gauge. Stimulation of the cervical sympathetic nerves at a frequency of 0-1 to 50 pulses/second causes the membranes to contract. The magnitude of the contractions is dependent on the frequency of... [Pg.136]

Short and Darby [215] have recently reported that 2-(2-methylthioethylamino) ethylguanidine (XXIII) relaxes the nictitating membranes of conscious cats, and... [Pg.141]

Amongst quaternary ammoniuin derivatives, the compounds (L, R = H, X = NMe3 and R = 5,8-Me2, X = NMe2Et) caused relaxation of the nictitating membranes in cats, although they were less active than guanoxan [94]. [Pg.158]

Relative activities (xylocholine = 1-0) from weight for weight comparisons of the subcutaneous doses necessary to relax the nictitating membranes of cats to cover 30% of the eyes. [Pg.160]

R R R r r Adrenergic neurone blocking activity Cat nictitating Ptosis in membranes micef [259] A n tihypertensive activity... [Pg.162]

Adrenergic neurone blocking activity is increased when substituents are introduced into the ortho- and para-positions of benzylguanidine (Table 3.18) active compounds include the bromo (a particularly close analogue of bretylium), chloro and trifluoromethyl derivatives (LIV, R = 2-Br, 2-Cl, 2- and 4-CFa) [140, 141, 239, 242]. The 4-trifluoromethyl derivative, which has a relaxing effect on the nictitating membrane of cats comparable in intensity and duration to bethanidine, also decreased blood pressure in hypertensive dogs [141]. Certain... [Pg.163]


See other pages where Cat nictitating membrane is mentioned: [Pg.136]    [Pg.139]    [Pg.149]    [Pg.157]    [Pg.164]    [Pg.164]    [Pg.168]    [Pg.176]    [Pg.334]    [Pg.314]    [Pg.317]    [Pg.571]    [Pg.408]    [Pg.416]    [Pg.177]    [Pg.32]    [Pg.136]    [Pg.139]    [Pg.149]    [Pg.157]    [Pg.164]    [Pg.164]    [Pg.168]    [Pg.176]    [Pg.334]    [Pg.314]    [Pg.317]    [Pg.571]    [Pg.408]    [Pg.416]    [Pg.177]    [Pg.32]    [Pg.514]    [Pg.49]    [Pg.50]    [Pg.137]    [Pg.137]    [Pg.140]    [Pg.142]    [Pg.147]    [Pg.152]    [Pg.156]    [Pg.159]    [Pg.160]    [Pg.161]    [Pg.163]    [Pg.163]    [Pg.270]    [Pg.289]    [Pg.294]    [Pg.295]    [Pg.41]   
See also in sourсe #XX -- [ Pg.408 , Pg.416 ]




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