Indo-pacific marine invertebrates

STRUCTURE-ACTIVITY RELATIONSHIPS OF BIO ACTIVE METABOLITES FROM SOME INDO-PACIFIC MARINE INVERTEBRATES... 

In this chapter, a rationale of the structure-activity relationships of various series of bioactive secondary metabolites from Indo-Pacific marine invertebrates is reviewed. These include alkaloids, terpenes and polybrominated diphenyl ethers which were subjected to a series of bioassays in search for insecticidal, antibacterial, fungicidal, and cytotoxic lead compounds. From these various biotests, it was observed that the bioactivity of an analogue is not due to general toxicity but rather possesses a degree of specificity on a particular target biomolecule. The relationship between chemical structures and biological activity is related to the specific action of a compound. 

Table 5. Bioactivity of Metabolites Isolated from Indo-Pacific Marine Invertebrates...

Proksch, P., Ebel, R., Edrada, R.A., Schupp, P., Lin, W.H., Wray, S.V., and Steube, K. (2003a) Detection of pharmacologically active natural products using ecology selected examples from Indo-Pacific marine invertebrates and sponge-derived fungi. PureAppl. Chem., 75, 343-352. 

A study of South Pacific marine invertebrates has revealed the new 1891 in the sponge Dysidea herbacea (1760). The new 1892 was isolated from Sagaminop-teron bilealbum molluscs feeding on the sponge Dysidea herbacea from Guam waters (1761). Four samples of Dysidea sponges from the Indo-Pacific yielded the... 

Prialt [Fig. 6] is a synthetic copy of a toxin from the Magician s cone snail. Conus magus, a mollusk from the Indo-Pacific region. This is also one of the first pharmaceuticals that demonstrate the promise that marine life, particularly invertebrates, holds for drug developers. 

The SIO-RU-SKB collaboration also involved the collection, in 1994 and 1995, of over 100 marine invertebrates from the Ponto do Ouro area of southern Mozambique, about 80kms north of Sodwana Bay Fig. (1). Two cyclic peptides, the known swinholide A (78) and the new bicyclic theopalauamide (79), were isolated from Mozambique specimens of the Indo-Pacific lithistid sponge Theonella swinhoei (Family Theonellidae) [79]. Interestingly, a concurrent investigation of T. swinhoei from Palau,... 

Kelecom, a., B. Tursch, and M. Vanhaelen Chemical Studies of Marine Invertebrates XIX. Glycosidic Chain Structure of Thelothurins A and B, Two New Saponins from the Indo-Pacific Sea Cucumber Thelenota ananas Jaeger (Echinodermata). Bull. Soc. Chim. Belg. 85, 277 (1976). 

Kelecom, A., Daloze, D and Tursch, B. (1976b) Chemical studies of marine invertebrates. XX. The stmctures of the genuine aglycones of thelothurins A and B, defensive saponins of the Indo-Pacific sea cucumber Thelonota ananas Jaeger (Echinodermata). Tetrahedron, 32, 2313-2319. 

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