Conus magus

Conus. Thus, Figure 6c shows a group of fish-hunting cones, the Conus magus-striatus group. Other piscivorous species such as Conus geographus are less closely related to the species shown in Figure 6c. 

McIntosh M, Cruz LJ, HunkapiUer MW, Gray WR, Ohvera BM. (1982) Isolation and structure of a peptide toxin from the marine snail Conus magus. Arch Biochem Biophys 218 329-334. 

Prialt [Fig. 6] is a synthetic copy of a toxin from the Magician s cone snail. Conus magus, a mollusk from the Indo-Pacific region. This is also one of the first pharmaceuticals that demonstrate the promise that marine life, particularly invertebrates, holds for drug developers. 

Conotoxin MVIIA, an N-type calcium channel blocker Conus magus... 

NMR Structure of Ziconotide A Novel Treatment for Pain. MVIIA, now known as Ziconotide, is a 25-amino acid peptide originally discovered from the venom of the marine cone snail. Conus magus. Like other to-conotoxins it is a potent blocker of N-type calcium channels, giving it a wide range of potential therapeutic applications. When delivered intrathecally (i.e., through spinal infu-... 

Elan Pharmaceuticals is developing SNX-111 (Ziconotide), the synthetic equivalent of cD-Conopeptide-MVIlA, found in the venom of the predatory marine snail Conus magus, for the treatment of severe pain and ischemia by the intrathecal or intravenous routes. The peptide has the structure H- Cys-Lys-Gly-Lys-Gly-Ala-Lys- Cys-Ser-Arg-Leu-Met-Tiy-Asp- Cys Cys-Thr-Gly-Ser- Cys-Arg-Ser-Gly-Lys- Cys-NH2cyclic(l 16),(8-20),(15-25)-tris(disulfide), which does not make it an... 

FIGU RE 5.1 Upper panel shows the sequence of CO-conotoxins isolated from Conus geographus (GVIA), Conus magus (MVllA, MVllC, and MVllD) and Conus Striatus (SVIA). Lower panel shows the arrangement of the cys residues that constitutes the four-loop structure. 

Ziconotide is a synthetic equivalent of a naturally occurring conopeptide found in the piscivorous marine snail. Conus magus. Ziconotide binds to N-type volt-age-gated calcium channels located on the primary nociceptive (Ap and C) afferent nerves in the superficial layers (Rexed laminae I and II) of the dorsal horn in the spinal cord. It was approved for use in the USA in 2004 for control of severe chronic pain. 

McIntosh, M., L.J. Cruz, M.W. Hunkapiller, W.R. Gray, and B.M. Olivera Isolation and Structure of a Peptide Toxin from the Marine Snail Conus magus. Arch. Biochem. Biophys. 218, 329 (1982). 

Kobayashi, J., H. Nakamura, and Y. Ohizumi Excitatory and Inhibitory Effects of a Myotoxin from Conus magus Venom on the Mouse Diaphragm, the Guinea-pig Atria, Taenia Caeci, Ileum and Vas Deferens. Eur. J. Pharmacol. 86, 283 (1983). Strichartz, G.R., G.K. Wang, J. Schmidt, R. Hahin, and B.I. Shapiro Modification of Ionic Currents in Frog Nerve by Crude Venom and Isolated Peptides of the Mollusc Conus striatus. Fed. Proc. 39, 2065 (1980). 

Ziconotide Phase III Conus magus Analgesic Peptide (m-conotoxin)... 

This compotmd, discovered in 1979, is in Phase III clinical trials, and a request for NDA approval submitted in 1999 was granted on 28th June 2000. On 28th December 2004, the FDA approved Prialt for the treatment of chronic pain by intrathecal injection. It is a very powerful analgesic (painkiller), approximately a thousand-fold more effective than morphine, but does not provoke any dependence effects. It was extracted from the venom of the mollusk Conus magus, collected in the Philippines. These cones are carnivorous sea snails that kill their prey (fish, moUusks and worms) by means of a very sophisticated system that is a true natural blowpipe. The microscopic arrows launched by the mollusk are coated with very powerful venoms, of which there are two principal types, a- and / -conotoxin. 

O-Conotoxin CVIA Conus magus (Mollusk) Peptide Inhibitor of calcium channels 186/1 mg... 

This compound is the exact equivalent of the 25-residue peptide isolated from the venom of the cone snail Conus magus under the name of ro-conopeptide MVIIA. Over 200 variations on the structure were made before the realization that the native peptide was the most effective. The Irish company Elan purchased the compound and rights and it was approved as stated earlier. In 2012 Olivera and collaborators published an excellent review in Biochemistry (Moscow) covering these peptidic cone snail agents, which should be read in conjunction with a review a year earlier by Daly and Craik from the University of Queensland. ... 

R., Varga, J., Gray, W. R. and Rivier, J. 1987. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using co-conotoxins from Conus magus venom. Biochemistry 26 2086-2090. 

Olivera, B.M., 1987, Neuronal Calcium channel Antagonists. Discrimination between Calcium Channel Subtypes using co-Conotoxin from Conus magus Venom, In Biochemistry, 26, 2086-209. 

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