Indinavir Rifampicin

NA /D, abd pain, bleeding, fevCT, T QT Interactions t Effects W7 atazanavir, clarithromycin, CT5rthromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfi-navir, ritonavir, saquinavir, telithromycin X effects W7 antacids, carbamazqjine, dexamethasone, phenobarbital, phenytoin, rifampicin, St. John s wort EMS Drug contains lactose, may cause D/abd discomfort in pts w/ lactose intolerance OD Sxs unknown symptomatic and supportive... 

Indinavir No Coadministration of indinavir with rifampicin is not recommended because rifampicin markedly decreases concentrations of indinavir... 

The use of rifampicin with the protease inhibitors indinavir, nelfinavir, and amprenavir is contraindicated. However, these agents can be used with rifabutin after appropriate dosage reduction. Failure to reduce the dosage of rifabutin can result in toxic manifestations, such arthralgia and uveitis. 

Clinically important, potentially hazardous interactions with indinavir, metoclopramide, rifabutin, rifampicin... 

Clinically important, potentially hazardous interactions with amantadine, anticholinergics, antidepressants, antimuscarinics, atazanavir, carbamazepine, clarithromycin, CYP2D6 inhibitors, CYP3A4 inducers, CYP3AF inhibitors, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, phenobarbital, phenytoin, rifampicin, ritonavir, saquinivir, St John s wort, telithromycin... 

Rifampicin (rifampin) bioavaiiabiiity is increased by indinavir, but amprenavir has no effect. Rifampicin markedly reduces the bioavailability of amprenavir, atazanavir/ritonavir, indinavir, indinavir with ritonavir, iopinavir/ritonavir, nelfinavir and saquinavir, but oniy modestiy reduces that of ritonavir. The effects of rifampicin on iopinavir/ritonavir and saquinavir/ritona-vir can be overcome by increasing the protease inhibitor dose, but this appears to increase adverse effects (hepatotoxicity). 

Rrfampidn (Rifampin). A study in 11 AIDS patients given indinavir 800 mg every 8 hours and rifampicin 600 mg daily for 14 days found that the AUC of rifampicin was increased by 73%. In a similar study looking at the effects of the rifampicin on indinavir, the indinavir AUC and maximum serum levels were decreased by 92% and 86%, respectively. In another study, giving rifampicin 300 mg daily for 4 days to 6 HIV-positive patients already receiving ritonavir-boosted indinavir (indinavir/ritonavir 800/100 mg twice daily) decreased the median indinavir plasma levels (measured 12 hours after the last dose) by 87% and the median ritonavir levels by 94%. ... 

Indinavir Rifabutin dose halved (150 mg daily or 300 mg three times per week). Indinavir dose increased (1 to 1.2 g every 8 hours). Not recommended (indinavir levels markedly reduced, rifampicin levels raised). 3,6-8... 

Jaruratanasirikul S, Sriwiriyajan S. Pharmacokinetics of rifampicin administered alone and with indinavir. JAntindcrob Chemother (1999) 44 (Suppl A), 58. 

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