INDEX phagocyte function

The phagocytic function of liver and spleen macrophages measured in vivo by the kinetics of blood clearance of colloidal carbon is similar in both lines (phagocytic index = 0.015 0.005 and 0.020 0.006 in High and Low line... 

Taplin, G. V., C. Finnegan, P. Noyes, and G. Sprague Blood retention of intravenously injected colloidal prodigiosin in normal and roentgen irradiated rabbits an index of phagocytic function in the reticuloendothehal system. Am. J. Roentgenol., Radium Therapy Nuclear Med. 71, 294 (1954). 

Colchicine has a long history of successful use and was the treatment of choice for many years. It is used infrequently today because of its low therapeutic index. Colchicine is thought to exert its anti-inflammatory effects by interfering with the function of mitotic spindles in neutrophils by binding of tubulin dimers this inhibits phagocytic activity. 

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