INDEX monitoring therapy with

Atypical antipsychotics Monitor for increased appetite with weight gain (primarily in patients with initial low or normal body mass index) monitor closely if rapid or significant weight gain occurs during early therapy cases of hyperlipidemia and diabetes reported. 

The peaks and troughs can be of practical importance with drugs of low therapeutic index, e.g. aminoglycoside antibiotics, and it may be necessary to monitor both for safe and effective therapy. 

Patients in hemodynamic subset I have a cardiac index and PAOP within generally acceptable ranges and have the lowest mortality of any subset. These patients do not need immediate specific interventions other than maximizing oral therapy and monitoring. It should be emphasized that patients with significant left ventricular dysfunction still may present in subset I because normal compensatory mechanisms and/or appropriate drug therapy at least partially may correct an otherwise abnormal hemodynamic profile. 

Because nearly 70% of patients who use alternative therapies do not inform their health-care providers about these products, pharmacists and other health-care professionals should question all patients about their use of alternative therapies. Health-care professionals should remain vigilant for potential interactions between alternative therapies and prescription medications, especially medications with a narrow therapeutic index, and should report suspected interactions to the FDA MedWatch program. The FDA recently established the Special Nutritionals Adverse Event Monitoring System, a searchable database including information about... 

The main way of determining vitamin K status, and monitoring the efficacy of anticoagulant therapy, is by measuring the time required for the formation of a fibrin clot in citrated blood plasma after the addition of calcium ions and thromboplastin — the prothrombin time. A more sensitive index is provided by direct measurement of preprothrombin in plasma, most commonly by immunoassay using antisera against preprothrombin that do not react with prothrombin. 

Vancomycin is a glycopeptide antibiotic used in the therapy of severe bacterial infections (49). The monitoring of vancomycin levels is recommended because of its narrow therapeutic index and toxicity. This measurement is especially appropriate for patients with unstable renal functions, who receive high doses of vancomycin or present serious bacterial infections accompanied by important sequestration of liquids when it could be difficult to achieve the optimal therapeutic dose. Most of the methods for vancomycin determination in routine practice are immimoassays. Chromatog-... 

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