Indane-2-carboxylic acid

Hydrolysis of dimethyl 3-methyl-3//-3-benzazepine-2,4-dicarboxyiate (3) with 50% sulfuric acid, or with 20% hydrochloric acid, effects loss of the nitrogen function and formation of the indane-2-carboxylic acid 4.25... 

Indane-2-carboxylic acid (89) has been converted in a similar manner (Scheme 16) to the hydrindene acid (90). A crucial step in the conversion of (-)-abietic acid into (+)-kaurene (93) and (-t-)-phyllo-cladene (94) involved the reduction of (91) to the mixture of epimers (92) combined with other doublebond isomers (Scheme 17). ... 

C10H10CI2N20 2-((3,4-dichlorophenoxy)methyl)-2-imidazolin 23712-05-2 25.00 1.3324 2 19162 C10H1002 indan-2-carboxylic acid 25177-85-9 27.69 1.0799 2... 

Ethyl phthalyl ethyl glycolate (2-ethoxy-1,3-dioxo-indan-2-carboxylic acid ester). A plasticizer compatible with PVC and most common thermoplastics. It has been approved by the FDA for use in food packaging. 

Moreover D-configuration could also be determined for the auxins (-l-)- -allyl-phenylacetic acid, (—)-indane carboxylic acid and (-)-i,2,3,4-tetrahydro-i-naphthoic acid (LVIII, LIX, LX). 

Chemical/Physical. Ozonation in water at 60 °C produced 7-formyl-1-indanone, 1-indanone, 7-hydroxy-l-indanone, l-indanone-7-carboxylic acid, indane-l,7-dicarboxylic acid, and indane-1-formyl-7-carboxylic acid (Chen et al, 1979). Wet oxidation of acenaphthene at 320 °C yielded formic and acetic acids (Randall and Knopp, 1980). The measured rate constant for the gas-phase reaction of acenaphthene with OH radicals is 8.0 x 10 " cmVmolecule-sec (Reisen and Arey, 2002). 

Hydrindene, see Indan Hydrindonaphthene, see Indan 1,8-Hydroacenaphthylene, see Acenaphthene Hydrobroinic ether, see Ethyl bromide Hydrocarbon propellant A-17, see Bntane Hydrochloric ether, see Chloroethane Hydrofuran, see Tetrahydrofuran Hydrogen carboxylic acid, see Formic acid Hydrophenol, see Cyclohexanol Hydroqninol, see Hydroquinone Hydroqninole, see Hydroquinone a-Hydroqninone, see Hydroquinone p-Hydroqninone, see Hydroquinone 6-Hydroxyacenaphthenone, see Acenaphthene Hydroxybenzene, see Phenol... 

Indane 1 formyl 7 carboxylic acid, see Acenaphthene 1-Indanone, see Acenaphthene, Fluorene... 

Electrophilic nitrations of aliphatic nitriles, carboxylic acids,carboxylic esters, ° and /3-diketones have been reported. The nitration of 2-alkyl-substituted indane-l,3-diones with nitric acid, followed by alkaline hydrolysis, is a standard laboratory route to primary nitroalkanes. ... 

Since the discovery of cis-1 -amino-2-indanol as a ligand for human immunodeficiency virus protease inhibitors and the development of a practical industrial process for the synthesis of either ris-isomers in enantiopure form, the remarkable properties of the rigid indane platform have been used extensively in an ever-increasing number of asymmetric methodologies. In addition to the use of this amino alcohol as a chiral auxiliary and ligand for asymmetric synthesis, it has found application as a useful resolution agent. Applications include amines, carboxylic acids, and alcohols. 

Antagonists of metabotropic glutamate receptors and G-protein-coupled receptors associated with various neurodegenerate diseases have been prepared by proline-catalyzed direct a-amination reactions (Scheme 2.30) [7c]. Both, indane carbaldehyde 10 and analogous compounds having an ester functionality [leading to l-aminoindan-l,5-dicarboxylic acid (AIDA)] and or a phosphonate substituent [(RS)-l-amino-5-phosphonoindan-l-carboxylic acid APICA], all reacted with di-... 

Process chemists studied an approach to 8 using the readily available indan-1-one-3-carboxylic acid 20 prepared from phenyl succinic anhydride via Friedel-Crafts closure (Scheme 6). After esterification (yielding 21), homologation of the carbonyl via aminomethylation proceeded in high efficiency to give 25. In the presence of... 

Diastereoselective asymmetric oxidative cyclization of m-l,2-divinylcyc ohexane is achieved if chiral carboxylic acids are employed as nucleophiles instead of acetic acid 2l 22 8b. Addition of various types of molecular sieves has a decisive influence on the oxidative cyclization of m-1,2-di-vinylcyclohexane, resulting in enhanced diastereoselectivities (up to 62 %), as well as in opposite absolute configuration [(lS,3a/, 7a5 ) or (l/ ,3aS.7a7 )] of the newly created centers in aryl-sub-stituted hexahydro-3-methylene-l-(l-oxo-2-phenoxypropoxy)indans 921. The origins of these effects, although not without precedence, are unclear. 

The first of these alternative approaches started with commercially available indanone-3-carboxylic acid 23 (derived from phenylsuccinic anhydride via Friedel-Crafts chemistry). This indanone was a viable precursor to 6 through an aminomethyl homologation with cyanide or nitromethane (Scheme 3.10). Our intent was to obtain ester 25, which after reduction would afford methylamine 28, which in turn would cyclize to generate lactam 29, giving benzazepine 6 upon reduction. Stereocontrol in the homologation was unnecessary, as lactam 29 would theoretically provide a thermodynamic sink under epimerizing reaction conditions, capturing the desired di-indane isomer. 

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