Inclusion body myositis, hereditary

Askanas V, Sarkozi E, Alvarez RB et al. (1996) Superoxide dismutase-1 gene and protein in vacuolated muscle fibers of sporadic inclusion-body myositis, hereditary inclusion-body myopathy, and cultured human muscle after beta-amyloid precursor protein gene transfer. Neurology 46, A487. 

Engel WK, Askanas V. (1998) Treatment of inclusion-body myositis and hereditary inclusion-body myopathy with reference to pathogenic mechanisms personal experience. In Askanas V, Serratice G, Engel WK (eds). Inclusion-body Myositis and Myopathies. Cambridge University Press, Cambridge, pp. 351-382. 

AskanasV, Engel WK. (1998) Sporadic inclusion-body myositis and hereditary inclusion-body myopathies diseases of oxidative stress and aging Areh Neurol 55... 

Mirabella M, Alvarez RB, Bilak M et al. (1996) Difference in expression of phosphorylated tau epitopes between sporadic inclusion-body myositis and hereditary inclusion-body myopathies. J Neuropathol Exp Neurol 55, 774-786. 

Koffman BM, Sivakumar K, Simonis T et al. (1998) HLA allele distribution distinguishes sporadic inclusion body myositis from hereditary inclusion body myopathies. J Neuroimmunol 84, 139-142. 

Argov Z, Sadeh M, Eisenberg I et al. (1998) Facial involvement in hereditary inclusion body myositis. Neurology 50, 1925-1926. 

This book contains chapters by internationally recognized experts and covers two currently very important topics muscle aging, and sporadic inclusion-body myositis, the most common aging-associated muscle disease. Also described are hereditary inclusion-body myopathies, which are genetically determined disorders pathologically rather similar to sporadic inclusion-body myositis but which become clinically manifest in early, or sometimes later, adulthood. 

Clinicalaspects of thish-IBMaredescribedin Chapter 12. We introduced the term "hereditary inclusion-body myopathy" (h-IBM) in 1993 [34] to specify hereditary muscle diseases with pathologic features like those of s-IBM except for a lack of lymphocytic inflammation hence the term "myopathy" instead of "myositis." However, olderh-IBMpatients may have slight inflammation in their muscle biopsies [35-37]. 

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