Incidence of drug interactions

Manchon ND, Bercoff E, Lemarchand P, Chassagne P, Senant J, Bourreille J. Frequence et gravite des interactions medicamenteuses dans une population agee etude prospective concernant 639 malades. [Incidence and severity of drug interactions in the elderly, a prospective study of 639 patients.] Rev Med Interne 1989 10(6) 521-5. 

The high incidence of drug-food and drug-drug interactions rules out monoamine oxidase inhibitors as antidepressants of first choice. However, there are circumstances in which these agents may be used effectively and successfully ... 

Public Flealth Service and the Infectious Diseases Society of America, as well as other experts in the area, do not recommend routine primary prophylaxis for OPC. The rationale includes effectiveness of therapy for acute episodes of OPC, low incidence of serious invasive fungal disease, low mortality associated with mucosal candidiasis, the potential development of resistant candidiasis, the possibility of drug interactions, and the prohibitive long-term cost of prophylaxis. For the same reasons, chronic suppressive therapy (i.e., secondary prophylaxis of recurrent OPC) is also not recommended routinely, but rather clinicians should treat each acute episode as it occurs. ... 

Drug is delivered directly to the site of pain, minimal systemic absorption and risk of toxicity, decreased incidence of drug-drug interactions, no need to titrate dosage, ease of use. 

Effectiveness of the three available phosphodiesterase inhibitors is essentially comparable, but differences exist in duration of action, and to a small degree, incidence of side effects and drug interactions. 

Adverse reactions are common and may include fever (63%), chills (57%), headache (40%), nausea (37%), diarrhea (37%), malaise (13%), dizziness (9%), leukopenia (57%), thrombocytopenia (37%), and generalized pain (46%).7,8,11 The incidence of infection is 37%, with CMV disease occurring in 13% of patients. There are no reported drug-drug interactions (DDIs) with the use of antithymocyte globulin at this time.7,8,11... 

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