Inbred, defined

Mice are a key element in many biological experimental designs, but their origin and quality are often overlooked. The variability introduced by using ill-defined mice, for example, randomly crossed strains, e.g., CD-I, or incomplete inbred... 

Mice (see Notes 1 and 2) any variety of mice can be used. Pathogen-free CD1 and NMRI mice from either sex have also been commonly used. As mentioned above, we recommend the use of inbred mouse strains since they are genetically well defined and uniform providing the advantage of high reproducibility not available with standard outbred mouse strains. In addition, due to the phenotypic uniformity of an inbred mouse strain, the sample size can be smaller than when using outbred stocks. 

Defined inbred line and may be unlike random outbred species... 

Altman, P.L., Katz, D.D. (1979). Inbred and genetically defined strains of laboratory animals Part 1, Mouse and rat. Fed. Am. Soc. Exp. Biol., Bethesda MD. 

The studies of Braun and Jaton (34) also indicated that rabbits belonging to the same inbred family group frequently produce antistreptococcal antibodies with k chains of the same subgroup and with remarkably similar N-terminal sequences. In some instances such antibodies also exhibit cross-idiotypic specificity (defined in Chapter 11, Section II,A). 

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