In vitro hydrolytic degradation

Chu, C.C., Hsu, A., Appel, M., and Beth, M. 1992. The effect of macrophage cell media on the in vitro hydrolytic degradation of synthetic absorbable sutures. 4th World Biomaterials Congress, April 27-May 1, 1992, Berlin, Germany. 

Stefani, M., Coudane, J. and Vert, M. (2006) Effects of polymerization conditions on the in vitro hydrolytic degradation of plaques of poly(dl-lactic add-block-ethylene glycol) diblock copolymers. Polymer Degradation and Stability, 91, 2853-2859. 

Chen, J., Gardella, J.A. (1999) Time-of-flight secondary ion mass spectrometry studies of in vitro hydrolytic degradation of biodegradable polymers. Macromolecules, 32, 7380-7388. 

Takahara A, Hergenrother RW, Corny AJ, Cooper SL. Effect of soft segment chemistry on the biostabihty of segmented polyurethanes. II. In vitro hydrolytic degradation and hpid sorption. J Biomed Mater Res 1992 26(6) 801-18. 

In Vitro Hydrolytic Degradation of Synthetic Biodegradable Biomaterials Having NO Function. 

Figure 8. Electron paramagnetic resonance (EPR) spectra of the degradation products from the in vitro hydrolytic degradation of TAM-polyglycolide in buffer media over a period of 55 days at 37 C. (A). 3 days (B) 23 days (C) 55 days. Note the presence of split peaks in (A) and (B) that was not there in (C).

Ginde, R. M. and Gupta, R. K., In vitro chemical degradation of poly(glycolic acid) pellets and fibres. Journal of Applied Polymer Science 33, 2411 (1987). Makino, K., Ohshima, H. and Kondo, T., Mechanism of hydrolytic degradation of poly(L-lactide) microcapsules effects of pH, ionic strength and buffer concentration. Journal of Microencapsulation 3, 203-212 (1986). 

Lee JW and Gardella JA. (2001) In vitro hydrolytic surface degradation of poly(glycolic acid) role of the surface segregated amorphous region in the induction period of bulk erosion. Macromolecules, 3928-3937. 

FIGURE 22 Semilog plot of the in vitro rate of hydrolytic chain scission of PCL, poly glycolic acid-co-lactic acid, and a 1 1 blend of the two polymers, demonstrating the use of blends to modify degradation rates. (From Refs. 64 and 65.)... 

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