In-source decay

J. J. Lennon and K. A. Walsh. Locating and Identifying Posttranslational Modifications by In-Source Decay During MALDI-TOF Mass Spectrometry. Protein Sci., 8(1999) 2487-2493. 

Note In particular the MALDI-TOF community has coined some sort of an own terminology, e.g., in-source decay (ISD) for all fragmentations occurring within the ion source, post-source decay (PSD) instead of metastable ion dissociation and fragment analysis and structural TOF (FAST) for the specific mode of operation of a ReTOF to detect metastable ions. 

Schnaible, V. Wefing, S. Resemann, A. Suckau, D. Biicker, A. Wolf-Kiimmeth, S. Hoffmann, D. Screening for Disulfide Bonds in Proteins by MALDI in-Source Decay and LlFT-TOF/TOF-MS. Anal Chem. 2002, 74, 4980-4988. 

T Pfeifer, M Drewello, A Schierhorn. Using a matrix-assisted laser desorp-tion/ionization time-of-flight mass spectrometer for combined in-source decay/post-source decay experiments. J Mass Spectrom 34 644—650, 1999. 

Bache, N., Rand, KD., Roepstorff, P., J0igensen, T.J.D. (2008) Gas-phase fragmentation of peptides by MALDl in-source decay with limited amide hydrogen (H-l/H-2) scrambling. Anal Chem, 80 (16), 6431-6435. 

Rand, K.D., Bache, N., Nedertoft, M.M., Jprgensen, T.J.D. (2011) Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay. Anal Chem, 83 (23), 8859-8862. 

Kocher, T, Engstrom, A., Zubarev, R.A. (2005) Fragmentation of peptides in MALDl in-source decay mediated by hydrogen radicals. Anal Chem, 77 (1), 172-177. 

Lemaire, R, Debois, D., Smargiasso, N., et al. (2013) Use of 1,5-diaminonaphthalene to combine matrix-assisted laser desorption/ionization in-source decay fragmentation with hydrogen/deuterium exchange. Rapid Commun Mass Spectrom, 27 (16), 1837-1846. 

V. Schnaible, S. Wefing, A. Resemann, D. Sukau, A. Biicka-, S. Wolf-Kummeth, and D. Hoffmann, Screening of disulfide bonds in proteins by MALDI in-source decay and LIFT-TOF/TOF-MS, Anal. Chem. 74, 4980-4988 (2002). 

Several gas-phase fragmentation techniques have found a niche as a possible means to sequence oligonucleotides. These include ESI in-source CID (nozzle-skimmer voltage to induce fragmentation), IRMPD in an FT-ICR MS instrument, MALDI in-source decay and post-source decay, and CID-MS/MS of the ESI-produced ions. CID generates complementary (a — B )- and in-type ions, which can provide bidirectional sequencing from the 5 3 direction and 3 5 ... 

Lennon JJ and Walsh KA (1999) Locating and identifying posttranslational modifications by in-source decay during MALDI-TOF mass spectrometry. Protein Science 8 2487-2493. 

S., Kenny, J., and Bailey, J. (1998) Unknown peptide sequencing using matrix-assisted laser desorption/ ionization and in-source decay. Anal. Chem., 70,1214-1222. 

Smargiasso, N., Quinton, L., and De Pauw, E. (2012) 2-Aminobenzamide and 2-aminobenzoic acid as new MALDI matrices inducing radical mediated in-source decay of peptides and proteins. J. Am. Soc. Mass Spectrom., 23, 469-474. 

Demeure, K., Quinton, L, Gabelica, V., and De Pauw, E. (2007) Rational selection of the optimum MALDI matrix for top-down proteomics by in-source decay. Anal. Chem., 79, 8678-8685. 

Sakakura, M. and Takayama, M. (2010) In-source decay and fragmentation characteristics of peptides using... 

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