Deuterium hydrogen exchange with

In support of this hypothesis it has been observed that when aluminum bromide is treated with oxygen a reaction occurs which liberates bromine,48 and further, the halogen atoms rather than the hydroxyl group are responsible for the catalytic activity of HOAlBr2. Thus when the compound DOAlBr2 is prepared, the hydrogen-deuterium exchange with n-butane is not at all proportional to isomerization.4 ... 

The alkanes produced in this interaction are certainly formed as a result of a hydrolytic cleavage of alkyl platinum derivatives. The close agreemmt betweai the ratio of methancs-d formed in platinum(ll) methylation and in direct hydrogen-deuterium exchange with alkanes [12] is a sound support for the formation of alkyl platinum derivatives in the homogeneous activation of alkanes. 

Alkanes reduce platinum(IV) to platinum(II) under conditions similar to those of hydrogen-deuterium exchange with the solvent (at 100-120 °C),... 

Li, Y, Williams, T.D., Schowen, R.L., Topp, E.M. (2007) Characterizing protein structure in amorphous solids using hydrogen/deuterium exchange with mass spectrometry. Anal Biochem, 366 (1), 18-28. 

Protons attached to the a-carbon atom in metal-carbene complexes undergo rapid base-catalyzed hydrogen-deuterium exchange with hydroxylic solvents (Kreiter, 1968). For example, the half-life for exchange of the a protons in VII in acetone-D20 with no added base is 23 min at 40° (Casey, 1970). This rapid exchange implies the existence of an intermediate carbanion. These... 

Azaindolizine, 5-chloro-nucleophilic substitution, 4, 458 8-Azaindolizine, 7-chloro-nucleophilic substitution, 4, 458 Azaindolizines basicity, 4, 454 electronic spectra, 4, 445 electrophilic substitution, 4, 453 halogenation, 4, 457 hydrogen/deuterium exchange, 4, 458 NMR, 4, 447, 449 nucleophilic attack, 4, 458 protonation, 4, 453 reaction with isothiocyanates, 4, 513 reactions, 5, 267 reviews, 4, 444 UV spectra, 4, 446, 449 Azaindolizines, amino-tautomerism, 4, 452... 

The stereochemistry of hydrogen-deuterium exchange at the chiral carbon in 2-phenylbutane shows a similar trend. When potassium t-butoxide is used as the base, the exchange occurs with retention of configuration in r-butanol, but racemization occurs in DMSO. The retention of configuration is visualized as occurring through an ion pair in which a solvent molecule coordinated to the metal ion acts as the proton donor... 

The growth of the catalytic activity of Si02 with respect to the hydrogen-deuterium exchange reaction upon addition of a donor impurity to specimens has also been observed by Taylor and his colloborators (31). 

The same authors (41) working with specimens of silica gel observed a positive photocatalytic effect in the course of the hydrogen-deuterium exchange reaction. In this case the introduction of an acceptor impurity into a catalyst enhanced the action of irradiation. 

Lunsford and Leland (42) studied the reaction of hydrogen-deuterium exchange on crystals of MgO containing V-centers. As known, a Y-center in an ionic crystal, being a cationic vacancy with a hole localized near it, plays the role of an acceptor. These authors have found that the photocatalytic effect is intensified as the concentration of V-centers in a crystal increases, which is in accord with the experiments carried out by Kohn and Taylor. 

Freund (44) studied the influence of ultraviolet light on the catalytic activity of zinc oxide in relation to the reaction of hydrogen-deuterium exchange. The author noted that the photocatalytic effect was positive and that it decreased with rising temperature. 

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