Imprinting Matrices

Molecularly imprinted matrices using proteins as the precursors... 

Arnold and co-workers proposed a novel and generic approach to prepare mole-cularly imprinted matrices for the selective recognition and binding of proteins [40], They used metal coordination interaction to induce complementary binding... 

The use of fibre optics should also prove to be very interesting. The formation of imprinted matrices directly on the optic fibre (Sections 20.2.5.6. and 20.2.5.7.) should overcome the shortcomings of Kriz s prototype (Section 20.2.5.1.). Thin membranes of MIP should vastly increase mass-transfer rates, reducing incubation times as well as obviating the need for physical entrapment of polymer particles. 

In addition to studies where the nature of the recognition events per se has been the major issue, a number of application areas have been explored for imprinted matrices viz. (A) Chromatography, where the imprinted polymer is used as the stationary phase for separation and isolation (Chapter 20). This application is based on the fact that the imprinted polymer has a better retention for the template molecules than others. A related area of application is solid-phase extraction, where the imprinted polymer is used as a sponge to concentrate the molecule of interest (Chapter 23). (B) Immunoassay-type analyses in which molecularly imprinted polymers are used as antibody and receptor mimics (Chapter 25). (C) Catalysis where the molecularly imprinted polymers are used as enzyme mimics (Chapter 24). (D) Sensors and biosensor-like devices where the molecularly imprinted polymer is the recognition element (Chapters 26 and 27). 

Arnold, F. Dhal, P. Shnek, D. Plnkett, S. In Template Polymerization Using Metal Chelates and Fluid Imprint Matrices for Use in Protein Purification. PCT International,... 

---