Immunosuppressive behavior

In vitro and in vivo studies have indicated that different organotin compounds show different cytotoxic effects on different types of cell lines. Thus, tributyltin and triphenyltin showed immunosuppressive behavior while trimethyltin and triethyltin compormds were nemotoxic. It is known that different organotin compounds show different effects on Na /K -ATPase activity. Fruther, different organotin halides have shown different effects on voltage-gated potassium currents in lymphocytes and nemoblastoma ceUs. ... 

Heart transplantation represents the final option for refractory, end-stage HF patients who have exhausted medical and device therapies. Heart transplantation is not a cure, but should be considered a trade between a life-threatening syndrome and the risks associated with the operation and long-term immunosuppression. Assessment of appropriate candidates includes comorbid illnesses, psychosocial behavior, available financial and social support, and patient willingness to adhere to lifelong therapy and close medical follow-up.1 Overall, the transplant recipient s quality of life may be improved, but not all patients receive this benefit. Posttransplant survival continues to improve due to advances in immunosuppression, treatment and prevention of infection, and optimal management of patient comorbidities. 

Given 0.05-15 mg/kg BW daily, chronic exposure Offspring showed behavioral effects at all doses at 15 mg/kg BW daily, reproduction was inhibited and offspring showed immunosuppression 2... 

There is a very broad range of toxic effects of dioxins. Many of the congeners can induce toxic responses at very low dose. The most sensitive effects are immunosuppression, developmental and reproductive toxicity, as well as neurological behavioral effects. Carcinogenic effects are induced at higher exposure. TCDD was considered a complete carcinogen by the International Agency for Research on Cancer, IARC [115]. 

Cyclosporine is an endecapeptide isolated from fungi. It is an immunosuppressive used to prevent rejection in organ transplantation. Studies have been carried out to investigate the effectiveness of inhalation of this compound in patients receiving lung transplants. Very rapid peak plasma levels were observed followed by a slow phase but the interpretation of this behavior is compromised by the low aqueous solubility of this compound. ... 

In a study conducted to obtain a better understanding of the functional and immunological consequences of Spheramine implantation in the presence and absence of systemic immunosuppression, 6-OHDA hemiparkinsonian rats were intrastriatally implanted with around 2000 cells attached to gelatin microcarriers and randomized into two groups, with and without cyclosporin A. The behavioral results from this short-term study showed a therapeutic benefit and no difference between groups, indicating that immunosuppression is not necessary. 

Given our ability to enhance the physicochemical behavior of this immunosuppressive drug using polymer-based formulation systems, we anticipate an alleviation of select adverse effects using disparate pharmaceutical dosage formulation strategies. 

ADER, R. COHEN, N. (1975) Behaviorally conditioned immunosuppression. Psychosomatic Medicine. 37, 333-340. 

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