Immunosuppression rifampicin

Ciclosporin is extensively metabolised its concentration in blood may be reduced due to enzyme induction by rifampicin, with danger of inadequate immunosuppression hazarding an organ or marrow transplant. 

There is no evidence that rifampicin causes clinically significant deleterious effects on the immune system in humans (78), whereas it can cause immunosuppression in animals (79). Rifampicin partially suppresses cutaneous hypersensitivity to tuberculin and T cell function (80). In 33 patients with leprosy treated with a rifampicin drug combination, a flu-like illness or antibodies to rifampicin-conjugated proteins were not observed (81). 

Sulfonamides, penicillins, diclofenac, oxyphenbutazone, piroxicam, phenytoin, carbamazepine (Same as for erythema multiforme) penicillamine, captopril, piroxicam, penicillins, rifampicin Frusemide, penicillamine, penicillin, PUVA therapy Immunosuppressants, mexiletine, thioridazine, penicillamine, moduretic , atenolol, quinacrine... 

Another suggested alternative is to replace the ciclosporin with another non-interacting immunosuppressant, such as azathioprine and low-dose prednisolone for immunosuppression, if rifampicin is needed."... 

Al-S aiman MH, Dhar JM, Al-Khader AA. Successful use of rifampicin in the treatment of tuberculosis in renal transplant patients immunosuppressed with cyclosporine. Transplantation (1990) 50,597-8. 

Kiuchi T, TanakaK, Inomata Y, Uemoto S, SatomuraK, Egawa H,UyamaS, SanoK, Okajima H, Yamaoka Y. E q)erience of tacrolimus-based immunosuppression in a livii -related liver transplantation complicated witii graft tuberculosis interaction witii rifampicin and side effects. Transplant Proc (1996) 28, 3171-2. 

Csonka GW, Rosedale N, Walkden L (1971) Balanitis due to fixed frug eruption associated with tetracycline therapy. Br J Vener Dis 47 42-44 Dajani BM, Canady MS, Thompson JS, Kasik JE (1972) Rifampicin an immunosuppressant Lancet 2 1094... 

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