Polio vaccines Immunosuppressants

Polio vaccine oral Immunosuppressant Anticancer Antifungal... 

For children up to age 16 years with HTV infection, immunization following the standard schedules is recommended for hepatitis B, DTaP, pneumococcal conjugate vaccine (PCV7), H. influenzae type b (Hib), inactivated polio vaccine (IPV), and annual influenza. Two doses of MMR vaccine should be administered at least 1 month apart as soon as possible after the first birthday. MMR should be administered only to children who have no evidence or moderate evidence of immunosuppression. Two doses of varicella vaccine separated by... 

In organ transplant recipients taking immunosuppressants, tetanus vaccines and inactivated polio vaccines produced protective antibody titres. The response to diphtheria vaccine was lower than in healthy controls and the antibody titre had fallen below the protective level by 12 months in 38% of patients in one study, and 24% in another. Note that live polio vaccines are not recommended in immunosuppressed patients (see Live vaccines, below). 

AZATHIOPRINE VACCINES i effectiveness of vaccines, t risk of adverse/toxic effects of live vaccines (e.g. measles, mumps, rubella, oral polio, BCG, yellow fever, varicella, TY21a typhoid), e.g. vaccinal infections Disseminated infection due to enhanced replication of vaccine virus in the presence of diminished immunocompetence Do not vaccinate when patients are on immunosuppressants. Vaccination should be deferred for at least 3 months after discontinuing immunosuppressants/myelosuppres-sants. If an individual has been recently vaccinated, do not initiate therapy for at least 2 weeks after vaccination... 

Appropriate immunizations should be a primary consideration in the prevention of infections in HSCT recipients. Immunizations against common bacterial and viral pathogens are timed to avoid periods of severe immunosuppression following HSCT when the protective response to vaccination potentially would be decreased. Current recommendations for immunization of HSCT patients include three doses each of diphtheria-pertussis-tetanus or diphtheria-tetanus, inactivated polio, conjugated H. influenzae type b, and hepatitis B vaccines at 12, 14, and 24 months after transplantation. The 23-valent pneumococcal vaccine should be administered at 12 and 24 months after HSCT, and the influenza vaccine should be administered prior to HSCT, resumed at least 6 months after transplantation, and con-... 

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