Role of the Side Chain in Immunological Reactivity

The acyl side chain at the C-7 position of the cephalosporins seems to play a major role in determining the specificity of antibodies raised by or reacting with cephalo- 

In those cases where it was investigated (Kuwahara et al. 1970), the substituents at C-3 did not appear to play a role in the antibodies specificity. 

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