Immune response to allergens

Akdis M Healthy immune response to allergens T regulatory cells and more. Curr Opin Immunol 2006 18 738-744. 

Fig. 2. Counter-regulatory effects of antigen-specificTreg cells in a peripheral immune response to allergen. 

Dearman RJ, Spence LM, Kimher I Characterization of murine immune responses to allergenic diisocyanates. Toxicol Appl Pharmacol 112 190-197, 1992... 

Marsh DG, Blumenthal MN, Ishikawa T, et al HLA and specific immune responsiveness to allergens in Tsuji K, Aizawa M, Sasazuki T (eds) HLA 1991. Proceedings of the Eleventh International Histocompatibility Workshop and Conference. Oxford, Oxford University Press, 1992, pp 765-771. (Ill)... 

An immune response to allergens results in release of inflammatory mediators that cause allergic rhinitis symptoms. Therefore patients must be thoroughly knowledgeable about the proper timing and administration of prophylactic regimens. 

Hypersensitivity (or allergy) describes an inappropriate immune response to foreign substances, allergens, giving rise to irritant or harmful reactions. 

Type I allergic reactions are inappropriate immune responses to an allergen with preferential synthesis of immunoglobulin E (IgE), a special antibody class, which binds to mast cells and basophilic granulocytes via Fee receptors. Binding of the allergen to the cell-bound IgE initiates the rapid release of allergic mediators, most prominently histamine, and the de novo synthesis of arachidonic acid metabolites and cytokines, which are responsible for the clinical symptoms. 

Allen, J.E., Lawrence, R.A. and Maizels, R.M. (1995) Fine specificity of the genetically controlled immune-response to native and recombinant gpl 5/400 (polyprotein allergen) of Brugia malayi. Infection and Immunity 63, 2892-2898. 

Dearman, R.J. and Kimber, I., Characterisation of immune responses to food allergens in mice. Proc. Nutr. Soc., 64, 426, 2005. 

Synthetically produced allergenic products intended to specifically alter the immune response to a specific antigen or allergen. 

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