Immobilized Cells and their Applications

One of the maj or problems with microorganism immobilization is the hmitation of mass transfer, particularly the depletion of oxygen inside the immobilization matrices. Because of the severe oxygenation problem, immobilization technology has been mainly confined to anaerobic processes in which either obhgate anaerobes are employed or only the anaerobic components of the facultative metabolic mechanisms are selectively utilized. 

Antibiotics Bacitracin (antimicrobial peptide) Bacillus spp. GU215 Adsorption on silicon polymer beads and wood chips [61] 

Neomycin Streptomyces marinensis Entrapment in calcium alginate beads [62] 

Vancomycin Amycolatopsis orientalis Entrapment in calcium alginate beads adsorption on synthetic cotton fibers, glass wool, and cotton cloth [64] 

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Immobilized Cells and their Applications 223 Table 7.3 Recombinant proteins produced by immobilized mammalian and insect cells. 

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