Ligand immobilization, high surface area

An interesting new concept of catalyst immobilization is the use of supported aqueous phase catalysts. Here, the catalyst is immobilized in a thin water layer adhered within the pores of a high-surface-area porous support. A new Rh catalyst of this class with ligand 11 is stable, recyclable, and highly selective in the hydroformylation of higher alkenes to linear aldehydes.236... 

High Surface Area Silica Particles as a New Vehicle for Ligand Immobilization on the Quartz Crystal Microbalance... 

In general, the site-specific immobilization methods described above are especially effective when the protein recognition site on ligand molecules is known or can be predicted. Small molecules immobilized on solid surfaces through a specific functional group uniformly present a certain area of their molecular surfaces, and thus the interaction with proteins that recognize this surface can be analyzed in a highly sensitive and quantitative manner. However, except in the case of certain protein-reactive small molecules [53], it is difficult to predict the... 

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