Immediate-Necessary-Sufficient

The immediate causes of the TOP event are shown in the fault tree with thek relationship to the TOP event. If any one of the immediate causes results dkecdy in the TOP event, the causes are connected to the TOP event with an OR logic gate. If all the immediate causes are requked for TOP event occurrence, then the causes are connected to the TOP event with an AND logic gate. Each of the immediate causes is then treated in the same manner as the TOP event, and its immediate, necessary, and sufficient causes are determined and shown on the fault tree with the appropriate logic gate. This development continues until all intermediate fault events have been developed into thek basic causes. 

CONSTRUCTING THE FAULT TREE. Fault tree construction begins at the top event and proceeds, level by level, until all fault events have been traced to their basic contributing events or basic events. The analysis starts with a review of system requirements, function, design, environment, and other factors to determine the conditions, events, and failures that could contribute to an occurrence of the undesired top event. The top event is then defined in terms of sub-top events, i.e., events that describe the specific "whens and wheres" of the hazard in the top event. Next, the analysts examine the sub-top events and determine the immediate, necessary, and sufficient causes that result in each of these events. Normally, these are not basic causes, but are intermediate faults that require further development. For each intermediate fault, the causes are determined and shown on the fault tree with the appropriate logic gate. The analysts follow this process until all intermediate faults have... 

The Immediate-Necessary-Sufflcienf (I-N-S) concept is a question the analyst should ask themselves when defining inputs to any particular gate. Have most immediate causes been identified, have all necessary causes been identified, but only those necessary and sufficient to lead to the event. 

The fundamentals of this method of protection are dealt with in Section 2.3 and illustrated in Fig. 2-15. Corrosion protection for the stable-passive state is unnecessary because the material is sufficiently corrosion resistant for free corrosion conditions. If activation occurs due to a temporary disturbance, the material immediately returns to the stable passive state. This does not apply to the metastable passive state. In this case anodic protection is necessary to impose the return to the passive state. Anodic protection is also effective in the unstable passive state of the material but it must be permanently switched on, in contrast to the metastable passive state. 

From the condition 21a it immediately follows that if the clathrate is formed in the presence of a number of compounds which are potential solutes, i.e., sufficiently small to have 0 for some i, all these compounds contribute to its stability. As has already been pointed out by Barrer and Stuart4 this at once explains the stabilizing influence of "Hilfsgase" such as air, C02, or H2S on the formation of gas hydrates discussed by Villard49 and von Stackelberg and Meinhold.47 If there is only one solute, Eq. 21a with the = sign determines the minimum vapor pressure fiA necessary to make the clathrate stable relative to Qa. Since all cavities contribute to the stabilization, one cannot say that this minimum pressure is controlled by a specific type of cavity. 

In the determination of cadmium in seawater, for both operational reasons and ease of interpretation of the results it is necessary to separate particulate material from the sample immediately after collection. The dissolved trace metal remaining will usually exist in a variety of states of complexation and possibly also of oxidation. These may respond differently in the method, except where direct analysis is possible with a technique using high-energy excitation, such that there is no discrimination between different states of the metal. The only technique of this type with sufficiently low detection limits is carbon furnace atomic absorption spectrometry, which is subject to interference effects from the large and varying content of dissolved salts. 

Sampling Interval To be able to perform valid toxicokinetic analysis, it is not only necessary to properly collect samples of appropriate biological fluids, but also to collect a sufficient number of samples at the current intervals. Both of these variables are determined by the nature of the answers sought. Useful parameters in toxico-kinetic studies are Cmax, which is the peak plasma test compound concentration Tmax, which is the time at which the peak plasma test compound concentration occurs, Cmin, which is the plasma test compound concentration immediately before the next dose is administered AUC, which is the area under the plasma test compound concentration-time curve during a dosage interval, and t which is the half-life for the decline of test compound concentrations in plasma. The samples required to obtain these parameters are shown in Table 18.12. Cmin requires one blood sample immediately before a dose is given and provides information on accumulation. If there is no accumulation in plasma, the test compound may not be detected in this sample. 

Starter packs are small packs designed to provide sufficient medicine for a primary care prescriber to initiate treatment in such circumstances as a call out in the night or in other instances where there might be some undesirable or unavoidable delay in having a prescription dispensed. It follows from this that the types of medicines for which starter packs are appropriate are limited to those where immediate commencement of treatment is necessary or desirable, such as analgesics and antibiotics. Starter packs are not samples and should not be labelled as such. The quantity of medicine in a starter pack should be modest, only being sufficient to tide a patient over until their prescription can be dispensed. 

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