Immature teratoma

Bing Z, Pasha TL, Lai P, et al. Expression of glial cell line-derived neurotropic factor receptor alpha-1 in immature teratomas. Am Clin Pathol. 2008 130 892-896. 

Juvenile granulosa cell tumors are stromal cell tumors of low malignant potential, which occur before the age of 30. Rarely, they occur before puberty and may become clinically apparent as precocious puberty. Immature teratomas are commonly associated with a mature teratoma they comprise 1% of all teratomas and occur most commonly in the first two decades of life. Tiunor markers are usually negative... 

Malignant germ cell tumors comprise, in order of decreasing frequency, dysgerminomas, immature teratomas, endodermal sinus tumors, and embryonal and nongestational choriocarcinomas. The latter three are extremely rare. In these patients, tumor markers may be helpful for assessing response and tumor recmrence. Endodermal sinus tumors secrete AFP. Embryonal carcinomas can secrete both AFP and HCG, whereas pure choriocarcinomas secrete only HCG [4]. 

The presence of fat is the diagnostic clue for the diagnosis of teratomas. Immature teratomas are usually large at presentation. In contrast to the majority of benign teratomas, which are cystic, malignant teratomas tend to be predominantly solid with small foci of fat and scattered calcifications. Elevation of alpha 1... 

Heifetz SA, Cushing B, Giller R et al (1998) Immature teratomas in children pathologic considerations. Am J Surg Pathol 22 1115-1124... 

Yamaoka T, Togashi K, Kbyama T et al (2003) Immature teratoma of the ovary correlation of MR imaging and pathologic findings. Eur Radiol 13313-319... 

Nogales FF, Avila IR, Concha A, et al. Immature endodermal teratoma of the ovary Emhryologic correlations and immuno-histochemistry. Hum Pathol. 1993 24 364-370. 

Ikeda K, Tate G, Suzuki T, et al. Cytomotphologic featutes of immature ovarian teratoma in peritoneal effusion A case te-port. Diagn Cytopathol. 2005 33 39-42. 

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