Juvenile granulosa cell tumor

Groisman GM, Dische MR, Fine EM, Unger PD. Juvenile granulosa cell tumor of the testis a comparative immunohis-tochemical study with normal infantile gonads. Pediatr Pathol. 1993 13 389. 

The second type of granulosa cell tumor that occurs in the ovary is the juvenile granulosa cell tumor.It occurs mainly in children and young women, but it can occur at any age, including in postmenopausal women. 

The tumor cells stain for inhibin and calretinin, " " " " and they usually show strong membrane staining for CD99 (Fig. 18.36).348 SF-1, WTl, and CD56 also are usually positive." Staining for cytokeratin is present in some tumors. Immunohistochemistry can help differentiate juvenile granulosa cell tumor from small cell carcinoma of the hypercalcemic type (see Table 18.9). 

Juvenile granulosa cell tumor is inhibin-positive, while small cell carcinoma does not stain for inhibin. 

FIGURE 18.36 juvenile granulosa cell tumor. Strong membrane staining for CD99 is present in nearly all juvenile granulosa cell tumors. 

Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovaty. A clinicopathological analysis of 125 cases. Am J Surg Pathol. 1984 8 575-596. 

Juvenile granulosa cell tumors are stromal cell tumors of low malignant potential, which occur before the age of 30. Rarely, they occur before puberty and may become clinically apparent as precocious puberty. Immature teratomas are commonly associated with a mature teratoma they comprise 1% of all teratomas and occur most commonly in the first two decades of life. Tiunor markers are usually negative... 

Fig. 10.28. Juvenile type of granulosa cell tumor. CT in a 17-year-old girl who presented with primary amenorrhea. A large, well-defined cystic ovarian tumor with multiple irregular septations and solid areas is demonstrated in the midpelvis. Small amounts of ascites (asterisk) without evidence of peritoneal seeding at surgery...

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