Imferon

Parenteral preparations Iron dextran (IMFERON) Iron-sorbitol citric acid complex (JECTOFER). 

Phenol 0.065-0.5 Humulin N, Zantac, Tensilon, Tagamet, Phenergan, Imferon... 

Fenaie Imferon Ironorm, Prepn London, Twigg, U.S,... 

The nurse is administering iron dextran (Imferon), an iron preparation, to a client diagnosed with iron-deficiency anemia. Which intervention should the nurse implement ... 

Extended X-ray absorption fine structure analysis of ferritin and imferon (a synthetic complex of iron oxide coated with dextran) show that the nearneighbour environment around the iron atom in the two macromolecules is identical. 

Iron-dextran, a synthetic therapeutic complex of iron oxide coated with dextran (Imferon ), has been shown to have properties similar to those of ferritin, a natural complex of iron oxide encased in protein.Both maintain high concentrations of iron in solution at physiological pH, and release iron relatively slowly in vivo. Extended AT-ray absorption fine structure analysis showed that the near-neighbour environment around the average iron atom in ferritin and iron-dextran is identical for the first three shells, which may explain the similarity of iron release in vivo. The results suggest that iron-dextran will be a useful model compound in studies of the relation of the iron core and protein in ferritin to function.i... 

Iron deficiency is commonly caused by insufficient dietary intake, excessive menstrual flow, multiple births, and gastrointestinal bleeding (occult or patent) due to medications (aspirin, steroids), hiatal hernia, peptic ulcers, gastritis associated with alcoholism, anemia of chronic disease, geophagia, and tumors. After these patients are carefully diagnosed, iron supplementation is administered using oral ferrous sulfate or by intravenous therapy with an iron-dextran complex (Imferon) [28,29]. 

Constant-potential coulometry [37,49] is presently employed to some extent for determining serum iron. Current generated at two electrodes with potentials of 460 and 325 mV is measured. Copper is reduced at both of them, while iron reduction occurs at one electrode (325 mV), so that copper can be blanked out. Iron-dextran (Imferon), sulfasalazine, and pyrazinamide interfere in this assay [37,49]. Iron-dextran is not detected in the dry-film Kodak assay for iron [49,55]. 

Hyaluronidase has been reported to elicit an oedematous reaction in the rat [58,160, 352, 353, 487, 534, 563] however, Benditt, Schiller, Mathews and Dorfman [62] showed that the spreading-factor activity and the oedema-producing factor of hyaluronidase are not the same. Other oedema-producing agents include the protein globulin [261, 303, 365,443, 563, 605,606], compound 48/80 [171, 371, 489], duodenal intrinsic factor and partially purified gastric mucin [308], soluble glycogen [10, 303] and Imferon - an iron-dextran complex [198-200, 307]. 

Mossbauer spectra of human liver ferritin (a), Imferon (b), Maltofer (c), and Ferrum Lek(d) measured atT = 295 K with a high velocity resolution and presented in 2048 channels (a, b, d) and in 4096 channels (c), indicated components are the results of the best fit and relationship between the spectral hyperfine parameters for Imferon ( ), Maltofer (A), Ferrum Lek ( ), and human liver ferritin (A) obtained using one quadrupole doublet fit (e) [129],... 

Theil, E.C., Sayers, D.E. and Brown, M. A. (1970) Similarity of the structure of ferritin and iron dexttan (imferon) determined by extended X-ray absorption fine structure analysis. Jourruil of Biological Chemistry, 17, 8132-4. 

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