Imaging mass spectrometry production

Koizumi S, Yamamoto S, Hayasaka T, Konishi Y, Yamaguchi-Okada M, Goto-Inoue N, Sugiura Y, Setou M, Namba H (2010) Imaging mass spectrometry revealed the production of lyso-phosphatidylcholine in the injured ischemic rat brain. Neuroscience 168 219-225. doi 10.1016/j.neuroscience.2010.03.056... 

Figure 18.6 Mass analyzers employed in imaging mass spectrometry research. A schematic representation of the NanoSIMS magnetic/ electric sector mass analyzer is depicted in the left-hand panel (http //www.cameca.fr/html/ product nanosims.html). A ToF mass analyzer...

Figure 5.11 Variation in the catalytic activity of an Mg(0001) surface when exposed to a propene-rich propene- oxygen mixture at room temperature. The surface chemistry is followed by XPS (a), the gas phase by mass spectrometry (b) and surface structural changes by STM (c, d). Initially the surface is catalytically active producing a mixture of C4 and C6 products, but as the surface concentrations of carbonate and carbonaceous CxHy species increase, the activity decreases. STM images indicate that activity is high during the nucleation of the surface phase when oxygen transients dominate. (Reproduced from Ref. 39).

An example of the application of the wide isolation window in tandem mass spectrometry is the detection and quantitative imaging of cocaine in postmortem human brain tissue (Reich et al., 2008 Reich et al., 2010). In this instance, it was determined necessary to develop an MS wide isolation window method because of interfering background ions. Cocaine detected in brain tissue was confirmed by matching six MS product ions with those from a cocaine standard. For the quantitation of cocaine analyzed from the tissue, the trideuterated ( Hs) internal standard was spiked beneath the tissue at known concentrations before matrix application to develop a calibration curve. The MS wide isolation method was then employed for the analysis of cocaine and cocaine-fi 3. Cocaine was analyzed successfully and quantified using this approach. 

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