Identification of pathways

Bjorklund M, Taipale M, Varjosalo M et al (2006) Identification of pathways regulating... 

Phase 2. Deductive identification of pathways leading to those states. 

Jorgensen, P., Nishikawa, J. L., Breitkreutz, B. J., Tyers, M. (2002). Systematic identification of pathways that couple cell growth and division in yeast. Science, 297, 395-400. 

Identification of Pathways. The expert system will guide a user to consider the variety of exposure pathways that should be considered for a site, and thus to perform a qualitative risk assessment. It helps to ensure that significant current or potential exposure pathways are not ignored. 

Adelman, S.J., Steffan, R.J. and Harnish, D.C. (2005) Identification of pathway-selective estrogen receptor ligands that inhibit NF-kB transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America, 102, 2543-2548. 

Seo H, Lee DY, Park S, Fan LT, Shafie S, Bertok B, et al. Graph-theoretical identification of pathways for biochemical reactions. Biotechnol Lett 2001 23 1551-7. 

The preparation of a matrix and the subsequent evaluation of the hazards identified can lead to a qualitative judgment of process risk and to the identification of available pathways to reduce that risk. Software is available to assist in making and maintaining interactionlike matrices. One example is a database shell called CHEMPAT (AIChE, 1995). When CHEMPAT is customized by the user, a compatibility chart is produced based on user-supplied chemical information. 

A substantial amount of indirect evidence supports the contention that the induction of apoptosis in tumor cells is critical to successful therapy. Cancer therapy might therefore be viewed as an attempt to induce apoptosis in a population of cells that have undergone selection for apoptotic defects. If correct, this hypothesis would suggest why cancer therapy is in many cases unsuccessful. However, recent studies indicate that this fundamental problem can be circumvented. Progress in the identification of molecules key to the cell death pathways has led to a growing understanding of how apoptosis occurs [3]. It has become clear that pathways to apoptosis are numerous and often interconnected. A solution to the clinical problem of therapeutic resistance, then, may lie in the fact that there appears to be multiple ways that a cell death program can be implemented. 

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