Identification of novel leads

Combinatorial chemistry was developed in the early 1990s with pharmaceutical industry being the main driver [3], The rapid screening of potential drug molecules against well-defined assays had quickly become one of the major tools for the identification of novel lead candidates. 

Identification of Novel Leads by High-Speed Countercurrent Chromatography Fractionation... 

In addition to extending the utility of analytical NMR, these developments have had a direct impact on screening methodologies, where NMR spectroscopy may now be used directly as a rapid and sensitive method for the characterization of binding affinities of mixtures of compounds in combinatorial libraries.3,9 11 A powerful screening method based on observation of NMR signals from a protein target has been developed by researchers at Abbott laboratories.12 Termed SAR (structure-activity relationship) by NMR, this technique has proved to be extremely valuable for the identification of novel lead compounds. 

Successful Identification of Novel Leads through Virtual Screening... 

Finn PW, Snarey M. Flexible three-dimensional database searching for the identification of novel lead compounds. In Bioactive Compound Design. Ford. Martyn G. (ed). Oxford. UK Bios Scientific Publishers. 1996 pp. 67-76. 

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