ICOS ligands

Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyfFRH, Umetsu DT Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002 8 1024-1032. 

Lam In your Sanroque mouse B cells do you see any changes in the levels of ICOS ligands ... 

ICOS ligands on the autoinvasive CDS T-ceUs [19, 48-51] (Figure 8.1). Of importance, the ICOS-positive T-cells are cytotoxic, expressing perforin granules [19]. Because both BBl and ICOS-L are functional molecules induced by IFN-y or TNFa on human myoblasts, in s-IBM the BB1/CD28 and the ICOS-ICOS-L interactions would partidpate in antigen presentation, clonal expansion, and costimulation of memory T-cells [50]. 

Schmidt J, Rakocevic G, Raju R, Dalakas MC. (2004) Upregulated inducible costimulator and ICOS-ligand in inclusion body myositis muscle significance for CD8-I- T cell cytotoxicity. Brain 127, 1182-1190. 

Complexes of cobalt(III) with O-donor ligands are generally less stable than those with Af-donors although the dark-green [Co(acac)3] and M iCo-( 204)3] complexes, formed from the chelating ligands acetylacetonate and oxalate, are stable. Other carboxylato complexes such as those of... 

IR ligand mode assignments (vC=0, vNH) have been proposed for [(L)Zn](C104)2 and [(L)Zn(H20)(NCCH3)](C104)2, where L = 6-R-2-pyridyl-methyl)-R, where R = NI ICO Bii and related.204 ATR-FTIR spectroscopy was used to characterise the coordination of Cd2+ to pyridine terminal groups of self-assembled bilayers.205... 

Number and geometry of the ligands. As we have seen, the point-charge model predicts that A for a tetrahedral complex will be only about 50% as large as for an octahedral complex, all other factors being equal. This approximate relationship is observed for VC14 and [VCy2-. as well as for ICo(NH3)4]2+ and [Co(NH3)ft]J+. 

The trinuclear ketenylidene complex, [FCs(iJ,s-C=C=0)iCO)gf 76, serves as a versatile starting compound for (i) heteronuclear ketenylidene complexes, (jj) 3-alkylidyne complexes (via G=GO bond cleavage), and (iii) G2 complexes (via conversion into /X3-G=G-OX ligands), as described in GOMG(1995). Treatment of 76... 

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