Ichikawa synthesis

Tanaka S. Takasu Y, Mikura S, Satoh N, Ichikawa A Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow-derived mast cells. J Exp Med 2002 196 229-235. 

Wong, C. H. Halcomb, R. L. Ichikawa, Y. Kajimoto, T., Enzymes in Organic-Synthesis - Application to the Problems of Carbohydrate-Recognition. 1. Chem. 

The first, made by Ichikawa et al. [29], was the evidence that rhodium or iridium cluster carbonyls, when adsorbed on zinc oxide, titania, lanthanum oxides, zirconia or magnesia, could produce quite selectively ethanol by the Fischer-Tropsch synthesis. This was a timely discovery (metallic catalytic particles produced by traditional methods could not reproduce such selectivity) since it came at a period of geopolitical tension after the Kippur war in 1973, which caused the price of crude oil to increase enormously. Therefore, that period was characterized by intense research into selective Fischer-Tropsch catalysis. 

C.H. Liang, S. Yao, Y.H. Chiu, P.Y. Leung, N. Robert, J. Seddon, P. Sears, C.K. Hwang, Y. Ichikawa, A. Romero, Synthesis and biological activity of new 5-0-sugar modified ketolide and 2-fluoro-ketolide antibiotics, Bioorg. Med. Chem. Lett. 15 (2005) 1307-1310. 

Taylor Katz McKillop Tetrahedron Lett. 1984,25, 5473. Uemura Ikeda Ichikawa Tetrahedron 1972, 28, 3025. Westmijze Vermeer Synthesis 1977, 784. 

Y. Ichikawa, J. L.-C. Liu, G.-J. Shen, and C.-H. Wong, A highly efficient multienzyme system for the one-step synthesis of sialyl trisaccharide In situ generation of sialic acid and TV-acetyllactosamine coupled with regeneration of UDP-glucose, UDP-galactose, and CMP-sialic acid, J. Am. Chem. Soc. 113 6300 (1991). 

C. H. Wong, R. L. Halcomb, Y. Ichikawa, and T. Kajimoto, Enzymes in organic synthesis Application to the problems of carbohydrate recognition (part 2), Angew. Chem. Int. Ed. Engl. 34 1010 (1995). 

P. Wang, G.-J. Shen, Y.-F. Wang, Y. Ichikawa, and C.-H. Wong, Enzymes in oligosaccharide synthesis Active-domain overproduction, specificity study, and synthetic use of an otl,2-mannosyltransferase with regeneration of GDP-Man, J. Org. Chem. 58 3985 (1993). 

G. F. Herrmann, Y. Ichikawa, C. Wandtey, F. C. A. Gaeta, J. C. Paulson, and C.-H. Wong, A new multi-enzyme system for a one-pot synthesis of sialyl oligosaccharides Combined use of P-galactosidase and a(2,6)-sialyltransferase coupled with regeneration in situ of CMP-sialic acid, Tetrahedron Lett. 34 3091 (1993). 

Usami Y, Horibe Y, Takaoka I, Ichikawa H, Arimoto M (2006) First Total Synthesis of (-)-Pericosine A from (-)-Shikimic Acid Structure Revision and Determination of the Absolute Configuration of Antitumour Natural Product Pericosine A. Synlett 1598... 

Fu H, Kondo H, Ichikawa Y, Look GC, Wong C-H (1992) Chloroperoxidase-Catalyzed Asymmetric Synthesis Enantioselective Reactions of Chiral Hydroperoxides with Sulfides and Bromohydration of Glycals. J Org Chem 57 7265... 

The histamine H3 receptor was first identified as an autoreceptor (Arrang et al. 1983), negatively regulating the synthesis and release of histamine in the CNS. Release-inhibiting H3 receptors have also been identified on terminals of various other neurons in the CNS and the periphery. Hi, H2 and H4 receptors function as presynaptic receptors rarely, if ever (Schwartz et al. 1986 Tanaka and Ichikawa 2006). 

Ichikawa et al. reported on the synthesis and antifungal activity of l-[(lfJ,2fi)-2-(2,4-difluorophenyl)-2-hydroxy-l-methyl-3-(l//-l,2,4-triazol-Tyl)propyl]-3-[4-(l//-l-tetrazolyl)phenyl]-2-imidazolidinone 597. Compound 597 was selected as an injectable candidate for clinical trials based on the results of evaluations of solubility, stability, hemolytic effect, and in vivo antifungal activities <2001CPB1102, 2001CPB1110>. 

Fukuoka, A., Higashimoto, N., Sakamoto, Y., Sasaki, M., Sugimoto, N., Inagaki, S., Fukushima, Y. and Ichikawa, M. Ship-in-bottle synthesis and catalytic performances of platinum carbonyl clusters, nanowires, and nanoparticles in microporous and mesoporous materials, Catal. Today, 2001, 66, 23-31. 

---