I-STAT

FIGURE 6-21 A silicon-based sensor array for monitoring various blood electrolytes, gases, and metabolites. (Courtesy of i-STAT Co.)... 

I -Stat (Westwood-Squibb) Theramycin Z (Medicis) generic and combination preparations... 

FIGURE 4.2 From top left, clockwise hand held i-STAT clinical analyzer and cartridge from Abbott Laboratories, bench top GEM 3000 clinical analyzer from IL, Inc., and large mainframe clinical analyzer UniCel DxC800 from Beckman Coulter, Inc. All these systems utilize ion-selective electrodes to determine clinically relevant electrolytes. 

During those two months when I wasn t on any medication, I was feeling pretty good and feeling kind of frisky in our relationship. I would say that Bevetly is. .. mote the doet, the task petson. Fm mote of a thinker, contemplative. And I think I statted to do mote things. I think that Bevetly was teacting to kind of a new petson when I got like that.. . and... 

Source VC I, Stat. Bundesamt. Mrneralolwiiischaltsverband, Qastatis, Dt. Bundesbank, BMA, BMG, VDR Fig. 8.3 Development of the price-cost squeeze in the German chemical industry. 

Another approach is the use of the potentiometric principle with planar thin film electrodes on a separate chip but in close vicinity to a FET input amplifier. Glucose and urea chips are now on the market commercialized by the company i-stat. These sensors are based on ion selective electrodes. The problems of stability are circumvented by a simple on chip calibration procedure and by the use of such microelectronic electrodes as disposable single shot probes for measuring Na, K, Cl, BUN, Glucose,iCa,pH,pC02 and Hct [56,57]. 

T. Mock, D. Morrison and R. Yatscofif, Evaluation of the i-STAT system a portable chemistry analyzer for the measurement of sodium, potassium, chloride, urea, glucose, and hematocrit, Clin. Biochem., 28 (1995) 187-192. i-STAT http //www.istat.com/products/docs/biosenso.pdf, 2002. 

Other Exatech E678 Accu Check II E349 Glucometer II E349, Chempro E508 und i-Stat 100 E691,... 

E691 Wilding, P. and Erickson, K.A. (1990). Evaluation of a hand-held micro-fabricated sensor system, the i-STAT 100, for rapid assay of electrolytes, glucose, urea nitrogen and hematocrit. Clin. Chem. 36, 1206, Abstr. 1185. 

Current address I-Stat Corporation, 303 College Road East, Princeton, NJ 08540... 

Cacoullos T. Estimation of a multivariate density. An I Stat Math 1966 18 179-89. 

Figure 10-1 The t-STAT system showing a cartridge and the microchip-based electrode assembly. (Reproduced by permission of i-STAT Corporation, East Windsor, NJ.)...

Erickson KA, Wilding P. Evaluation of a novel point-of-care system, the i-STAT portable clinical analyzer. Clin Chem 1993 39 283-7. 

Jacobs E, Vadasdi E, Sarkozi L, Colman N. Analytical evaluation of i-STAT Portable Chnical Analyzer and use by nonlaboratory health-care professionals. Clin Chem 1993 39 1069-74. 

Bingham D, Kendall J, Clancy M. The portable laboratory an evaluation of the accuracy and reproducibility of I-STAT. Ann Clin Biochem 1999 36 66-71. 

Davis G. Microfabricated sensors and the commercial development of the i-Stat point-of-care system. In Ramsay G, ed. Commercial Biosensors. New York John Wiley Sons, 1998 47-76. 

S. Senn and F. Ezzet, Clinical cross-over trials in phase I. Stat Methods Med Res 8 263-278 (1999). 

One of the first examples of a linear actuated device was the i-STAT for quantitative bedside testing, introduced in the early 1990s by Abbott Point of Care Inc., NJ, USA. It relied on active liquid actuation by displacement... 

Figure 5. Images and handling procedure of the i-STAT analyzer, (a) Photograph depicting the portable i-STAT analyzer for clinical blood tests [91], (b) Depending on the blood parameters to be measured, a certain disposable cartridge is filled with blood by capillary forces from the finger tip. (c) Afterwards loaded into the analyzer for assay processing and readout. (Images courtesy of Abbott Point of Care.)...

K. A. Erickson and P. Wilding, Evaluation of A Novel Point-Of-Care System, the I-Stat Portable Clinical Analyzer, Clinical Chemistry, vol. 39, no. 2, pp. 283-287, Feb. 1993. 

B. S. Karon, R. D. Mcbane, R. Chaudhry, L. K. Beyer, and P. J. Santrach, Accuracy of capillary whole blood international normalized ratio on the CoaguChek S, CoaguChek XS, and i-STAT 1 point-of-care analyzers, American Journal of Clinical Pathology, vol. 130, no. 1, pp. 88-92, 2008. 

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