Hypromellose capsule

Hypromellose capsules are manufactured using the same conditions to similar specifications. The main difference in the process is that the speed of output is slower because their gelling system takes longer to set than gelatin solutions, which rapidly change from the sol to the gel state. 

Hypromellose does not react with aldehydes or other agents that cause cross-linking of gelatin. Hypromellose capsules start to release their contents slightly slower than gelatin ones because of the slower rate of diffusion of water through the shell walls. However, once dissolution has commenced, the rates are similar and the results are comparable. ... 

The in vivo performance of gelatin and hypromellose capsules using gamma scintigraphy has been compared... 

Pharmacopeias require that hard capsules be tested in the same apparatus as tablets even though they have very different physical properties. Filled capsules contain entrapped air, and most formulations will float on water. Devices are required to ensure that they sink, and these can influence the results obtained. Gelatin and hypromellose are adhesive materials and tend to block wire meshes that form part of the standard equipment. The way in which capsules disintegrate and dissolve is dependent upon several factors such... 

In oral products, hypromellose is primarily used as a tablet binder, in film-coating, and as a matrix for use in extended-release tablet formulations.Concentrations between 2% and 5% w/w may be used as a binder in either wet- or dry-granulation processes. High-viscosity grades may be used to retard the release of drugs from a matrix at levels of 10-80% w/w in tablets and capsules. 

In addition, hypromellose is used in the manufacture of capsules, as an adhesive in plastic bandages, and as a wetting agent for hard contact lenses. It is also widely used in cosmetics and food products. 

Included in the EDA Inactive Ingredients Guide for use in oral preparations (capsules, and delayed-action preparations). Hypromellose acetate succinate has been approved for use in commercial pharmaceutical products in the USA and in Japan. 

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