Hypoxia-induced factor-1 HIF

Benita Y, Kikuchi H, Smith AD et al (2009) An integrative genomics approach identifies hypoxia inducible factor-1 (HIF-1 )-target genes that form the core response to hypoxia. Nucleic Acids Res 37 4587-4602... 

Himor Cells in Hypoxia Hypoxia-Inducible Factor-1, HIF-1... 

Other promoters that may be useful for the design of targeted vectors are those induced by disease-specific conditions, such as hypoxia (see Table 1). Thus, a promoter responding to hypoxia through activation by the hypoxia-inducible factor-1 (HIF-1) has been successfully used for experimental cancer gene therapy [69], Disease-specific conditions in tumor cells can also directly result from genetic alterations or from altered signaling pathways. The latter are presumably... 

Lauzier MC, Page EL, Michaud MD, Richard DE. 2007. Differential regulation of hypoxia-inducible factor-1 (HIF-1) through receptor tyrosine kinase transactivation in vascular smooth muscle cells. Endocrinology 148 4023-4031. 

Jiang, B. H., Agani, F., Passaniti, A., and Semenza, G. L. (1997). V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1 involvement of HIF-1 in tumor progression. Cancer Res. 57, 5328-5335. 

Michel G, Minet E, Ernest I, Roland I, Durant F, Remade J, Michiels C. A model for the complex between the hypoxia-inducible factor-1 (HIF-1) and its consensus DNA sequence. I. Biomol. Struct. Dyn. 2000 18 169-179. 

H, Kanopka A, Poellinger L, Haneda M, Morimoto C. Tran- 50. scriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1) a negative 51. feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. J. Biol. Chem. 2007 282 14073-14082. 52. 

Raval RR, Lau KW, Tran MGB, Sowter HM, Mandriota SJ, Li J-L, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIE-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 2005 25 5675-5686. 

Shock-dependent initialising mechanisms cause the induction of iNOS, COX-2, and CD 14. The early response genes, iNOS and COX-2, promote the inflammatory response by the rapid and excessive production of NO and prostaglandins. The transcription factor hypoxia-inducible factor-1 (HIF-1) may also regulate the induction of iNOS during the ischemic phase of shock, contributing to the excess NO formation. 

Rissanen E, Tranberg HK, Sollid J, Nilsson GE, Nikinmaa M. 2006b. Temperature regulates hypoxia-inducible factor-1 (HIF-1) in a poikilothermic vertebrate, crucian carp (Car-assius carassius). J Exp Biol 209 994-1003. 

Semenza GL (2007) Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 407 cm8-cml2. 

Two oxygen-sensing mechanisms help cells respond to oxygen deprivation one mechanism activates transcription of hypoxia-induced factor 1 (HIF-1), and the other promotes stabilization of HIF-1 by inhibiting its proteasomal degradation. 

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