Hypoxia adaptation

Rosenberger C, Goldfarb M, Shina A, Bachmann S, Frei L), Eckardt K-U, SchraderT, Rosen S, and Heyman SN. Evidence for Sustained Renal Hypoxia and Transient Hypoxia Adaptation in Experimental Rhabdomyolysis-induced Acute Kidney Injury. Nephrol Dial Transplant doi 10.1093/ndt/gfm808,2007. 

Body iron content is the principal factor in the regulation of iron absorption (Marx,1979a,b). However, other physiological variables, such as erythropoietic rate (Bothwell, 1968), hypoxia (Raja et ah, 1988) and inflammation (Weber et ah, 1988) also influence iron absorption. In normal individuals, if the rate of erythropoiesis is stimulated by blood loss, dyserythropoiesis or acute haemolysis, iron absorption is increased. Conversely, if erythropoiesis is inhibited by hypertransfusion, starvation or descent from high altitude to sea level, then iron absorption decreases. The adaptive response of iron absorption to increased erythropoiesis, stimulated... 

Reinheckel T et al. Adaptation of protein carbonyl detection to the requirements of proteome analysis demonstrated for hypoxia/reoxygenation in isolated rat liver mitochondria. Arch Biochem Biophys 2000 376 59-65. 

The rate and extent of these changes are consistent with metabolic adaptations to hypoxia rather than impairment of uptake due the changes in root morphology. Thus Kronzucker et al. (1998a) argue that the initial up-regulation of NH4+ influx was a response to cytoplasmic acidosis involving decarboxylation of N... 

Fig. 3. Radiosensitization of hypoxic V79 cells by 500 iM carboplatin compared to hypoxia without drug. The carboplatin data are corrected for cytotoxicity from the drug. Cells were exposed to carboplatin for 1 h at 37°C before irradiation. Adapted from Douple et al. (63).

Ri-measured PO2. Global Ischemia showed complete hypoxia for both groups with or without KCI arrest. Error bars represent one standard deviation of measurements from multiple hearts (data adapted from Ph.D. thesis of HImu Shukla, UT Southwestern 1994) [405]. 

It is known that the development of complications in postoperative period and their severity mostly depend on patient s adaptation capabilities to cope with the anaesthetic stress. Complications associated with anesthesia can be aggravated by the influence of other concomitant pathology, including the progression of hver tissue hypoxia [1 ]. 

Iron deficiency is the most common cause of chronic anemia. Like other forms of chronic anemia, iron deficiency anemia leads to pallor, fatigue, dizziness, exertional dyspnea, and other generalized symptoms of tissue hypoxia. The cardiovascular adaptations to chronic anemia—tachycardia, increased cardiac output, vasodilation—can worsen the condition of patients with underlying cardiovascular disease. 

Oxygen Sensing Responses and Adaptation to Hypoxia, edited by S. Lahiri, G. L. Semenza, and N. R. Prabhakar... 

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