Cytoplasmic acidosis

Roberts, J.K.M., Andrade, F.H. Anderson, I.C. (1985). Further evidence that cytoplasmic acidosis is a determinant of flooding intolerance in plants. Plant Physiology, 77, 492-4. 

The rate and extent of these changes are consistent with metabolic adaptations to hypoxia rather than impairment of uptake due the changes in root morphology. Thus Kronzucker et al. (1998a) argue that the initial up-regulation of NH4+ influx was a response to cytoplasmic acidosis involving decarboxylation of N... 

Lactic acid—causes cytoplasmic acidosis (lower cytoplasmic pH)... 

When a 59-year-old man took 10 g of podophyllum in a fatal suicide attempt he did not develop symptoms until 10 hours later, with loss of reflexes, coma, and marked lactic acidosis there were nuclear and cytoplasmic changes in circulating leukocytes (1). Despite hemo-perfusion, he died after 39 hours. 

Bjerneroth G, Sammeli 0, Li Y-C et al 1994 Effects of alkaline buffers on cytoplasmic pH in lymphocytes. Critical Care Medicine 22 1550-1556 Boilaert P E, Levy B, Nace L et al 1995 Hemodynamic and metabolic effects of rapid correction of hypophosphatemia in patients with septic shock. Chest 107 1698-1701 Bonagura J D, Reef V B 1998 Cardiovascular diseases. In Reed S M, Bayly W M (eds) Equine internal medicine. Saunders, Philadelphia, PA, pp. 290-370 Bonventre J V, Cheung J Y 1985 Effects of metabolic acidosis on viability of cells exposed to anoxia. 

Li Y-C, Wiklund L, Bjerneroth G 1997 Influence of alkaline buffers on cytoplasmic pH in myocardial cells exposed to hypoxia. Resuscitation 34 71-77 Lloyd M H, lies R A, Simpson B R et al 1973 The effect of simulated metabolic acidosis on intracellular pH and... 

With insufficient oxygen to meet the muscle demands, NADH levels increase in the mitochondria and in the cytoplasm, ADP and AMP concentrations in the cytoplasm will rise, and glucose will be shunted to the glycolytic pathway in the muscle. The pyruvate is converted to lactate, which causes the metabolic acidosis. 

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