Hypothesis for mechanism

Crane, R. K., 1962, Hypothesis for mechanism of intestinal active transport of sugars. Fed. Proc. 21 891. 

Sigler, P.B., et al. Structure of crystalline a-chymotrypsin II. A preliminary report including a hypothesis for the activation mechanism. /. Mol. Biol. 35 143-164, 1968. 

To gain an insight into the likely hydrolytic behavior of sulfated simple sugars and polysaccharides, Brimacombe, Foster, Hancock, Overend, and Stacey carried out a rigorous set of experiments with the cyclic sulfates of cyclohexane cis-and trims-1,2-diol as model compounds. The results were interpreted on the reasonable assumption that, in all cases, the cyclic sulfates initially afford a diol monosulfate. Examples of both S-0 and C-0 bond cleavage were encountered. A qualitative reaction mechanism was proposed for use as a working hypothesis for the hydrolysis of sugar sulfates. 

Evaporation-of-microlayer theory. A later hypothesis for the mechanism of nucleate boiling considers the vaporization of a micro layer of water underneath the bubble. This was first suggested by Moore and Mesler (1961), who measured... 

In outline of what follows we will begin by brief reference to previous work on coal liquefaction. The present approach will then be motivated from considerations of coal structure and hydro-gen-donor activity. A theoretical section follows in the form of a pericyclic hypothesis for the coal liquefaction mechanism, with focus on the hydrogen transfer step. Experiments suggested by the theory are then discussed, with presentation of preliminary results for hydrogen transfer among model substrates as well as for the liquefaction of an Illinois No. 6 coal to hexane-, benzene-, and pyridine-solubles by selected hydrogen donors. 

Kakimoto K, Takekoshi S, Miyajima K, et al. Hypothesis for the mechanism for heat-induced antigen retrieval occurring on fresh frozen sections without formalin-fixation in immunohistochemistry. J. Mol. Histol. 2008 39 389-399. 

Links, J. An hypothesis for the mechanism of (phobo-) chemotaxis. II. The carotenoids, steroids and fatty acids of Polytoma uvella. Thesis, Leiden, 1955... 

The mass fraction f2 increases strongly in the order Li-, Na-, K-, and Cs-oxide/ carbonate. However, the increase of the growth probability a2 is the same for all alkali promoters. The growth probability a and, consequently, mechanism 1 are not affected. Therefore, it is necessary to modify only mechanism 2 of the novel hypothesis for alkali ions to take part in the catalytic cycle.13... 

The second popular hypothesis for the therapeutic mechanism of action of Li+ is its interference with another receptor-coupled, second messenger system, that of the plasma-membrane bound enzyme, adenylate... 

Mehendale HM. 1990b. Potentiation of halomethane hepatotoxicity by chlordecone A hypothesis for the mechanism. Med Hypotheses 33(4) 289-299. 

Similar i-E-t relationships are derived theoretically from basic equations (simulation, see Section 1.4.1), on the basis of a hypothesis for the reaction mechanism, and the experimental and the theoretical results are compared. In this way, the hypothesis is either disproved, or proven to be consistent with the events at the electrode. 

These observations form the basis for the working hypothesis for the mechanism of cluster assembly on the IscU scaffold (Fig. 5.6). The proposal that the reductive coupling of two [Fc282] " clusters to yield a 6484] " cluster involves disulfide formation between two of the released cysteine residues is based on model chemistry. Flohn and co-workers showed that... 

There have been several attempts to provide a unifying hypothesis for the mechanism by which anthocyanins provide protection against such a diverse assortment of environmental stressors. Steyn et al. argued that because light can become toxic to green tissues under... 

The major current working hypothesis for lithium s therapeutic mechanism of action supposes that its effects on phosphoinositol turnover, leading to an early relative reduction of myoinositol in human brain, are part of an initiating cascade of intracellular changes. Effects on specific isoforms of protein kinase C may be most relevant. Alterations of protein kinase C-mediated signaling alter gene expression and the production of proteins implicated in... 

It was possible for two of the systems chosen that the nucleation and crystallization activation energies could be determined separately by distinguishing the induction period and crystal growth period in the overall crystallization process. Of the two hypotheses proposed for zeolite crystallization, in the gel phase or from the solution phase, the data support the latter hypothesis for crystal growth with the crystal-liquid surface enhancing the nucleation process in seeded systems. The precise mechanism of nucleation in unseeded systems remains to be determined. 

Our present working hypothesis for the mechanism of this water-gas shift catalyst system remains essentially the same as it was initially presented (99). The catalytic cycle consists of two separate reactions, with the rhodium alternating between the Rh(I) and Rh(III) oxidation states. 

The Watson and Crick hypothesis for DNA replication proposed that each strand of DNA is used as a template for the production of one of the daughter DNA molecules. Thus the result of replication would he that one strand of DNA is present in each daughter molecule of DNA. This is a semi-conservative mechanism of replication. A simplified diagram of replication is shown in Fig. S.AIO however, the replication patterns are different in bacteria and in eukaryotes. 

Mitchell postulated the chemiosmotic hypothesis for the mechanism of oxidative phosphorylation. 

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