Hypothermia acute ischemic stroke

Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke what do laboratory studies teach us Stroke 2004 35 1482-1489. 

Krieger DW, De Georgia MA, Abou-Chebl A, Andrefsky JC, Sila CA, Katzan IL, Mayberg MR, Furlan AJ. Coohng for acute ischemic brain damage (cool aid) an open pilot study of induced hypothermia in acute ischemic stroke. Stroke 2001 32 1847-1854. 

Guluma KZ, Hemmen TM, Olsen SE, Rapp KS, Lyden PD. A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke methodology. Acad Emerg Med 2006 13(8) 820-827. 

Potential Barriers to Combination Hypothermia and Neuroprotective Treatment in Acute Ischemic Stroke... 

Nevertheless, the possibility of combining hypothermia with other types of neuroprotection or thrombolysis is intriguing, and certainly deserves future study. However, if this treatment is ever to impact clinical practice, it is essential that appropriate preclinical studies be conducted. In particular, the rigorous evaluation of these combinations in a variety of ischemic models that most closely simulate the pathophysiology of acute ischemic stroke, is needed. Only after such extensive testing should the possibility of combination therapy be subsequently evaluated in randomized clinical trials. 

Georgiadis D., Schwarz S., Kollmar R., and Schwab S. (2001) Endovascular cooling for moderate hypothermia in patients with acute ischemic stroke. Stroke 32, 2550-2553. 

Deliberate mild hypothermia has been shown to be an extremely effective means of neuroprotection during periods of ischemia in experimental models. Intraoperative mild hypothermia has become a standard of practice for many neurosurgeons performing complex intracranial procedures. Recent findings of neurologic benefit in prospective, randomized, controlled clinical studies of cardiac arrest patients are encouraging, but more research is required to confirm and extend these positive results to other patients with stroke and traumatic insults. Further investigation must be completed to establish the optimal time and duration when treatment should be instituted to offer the optimal protection for patients with acute ischemic and traumatic injuries. 

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