Endovascular cooling

De GeorgiaMA, Krieger DW, Abou-Chebl A, Devlin TG, Jauss M, Davis SM, Koroshetz WJ, Rordorf G, Warach S. Cooling for acute ischemic brain damage (cool aid) a feasibility trial of endovascular cooling. Neurology 2004 63 312-317. 

Georgiadis D., Schwarz S., Kollmar R., and Schwab S. (2001) Endovascular cooling for moderate hypothermia in patients with acute stroke first results of a novel approach. Stroke 32, 2550-2553. 

Steinberg G. K., Bell-Stephens T., Shuer L. M., et al. (2003) Comparison of endovascular cooling to surface-cooling during unruptured cerebral aneurysm repair. Stroke 34, 246. 

De Georgia M. A., Abou-Chebl A., Krieger D. W., Andrefsky J. C., Sila C. A., and Furlan A. J. (2002) Endovascular cooling for patients with acute ischemic stroke. Stroke 33, 271. 

Dixon SR, Whitboum RJ, Dae MW, et al. Induction of mild systenuc hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol 2002 40 1928-1934. 

De Georgia et al. Stroke 2004 63 312-317 Prospective, randomized cooling vs. standard therapy for feasibility and safety 18 of40tx with hypothermia Hypothermia to 33°C with endovascular catheter on safety in pts with anterior circulation stroke and NIHSS >8 Similar clinical outcomes and lesion growth as measured on DWI MRI. Nonsignificant reduction in DWI volume in patients who cooled well. 

Georgiadis et al. Stroke 2002 33(6) 1584-1588 Nonblinded prospective hemicraniectomy for nondominant and cooling for dominant hemisphere 19 of 36 tx with hypothermia Hypothermia to 33°C with cooling blankets or endovascular technique on clinical course in pts with >2/3 MCA infarct 12% vs. 47% mortality for surgery vs. hypothermia. Hypothermia with increased complications of hypotension and electrolyte abnormalities. Both tx with longer ICU course... 

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