Hypophosphatemia with

X-linked hypophosphatemic rickets is characterized by defective proximal renal tubular phosphate transport and impaired renal production of 1,25-dihydroxycolecalci-ferol. These abnormalities lead to renal phosphate wasting, hypophosphatemia with normocalcemia, low plasma 1,25-dihydroxycolecalciferol concentrations, and... 

DEFICIENCY Deficiency causes hypocalcemia and hypophosphatemia, with resultant rickets (bending with poor calcification of developing bone in riuldren) or osteomalacia (decalcification and sofietring of bones in adults). In both of these there is impaired mineralization. These should be distinguished from another condition, osteoporosis, in which there is reductioii in bone mass as a whole, rather than select reduction of the mineral content. 

A 72-year-old man was treated with ceftriaxone (2 g bd) and gentamicin (80 mg tds) for a severe urinary tract infection (75). On day 5 his serum potassium concentration was 3 mmol/1 with a normal serum creatinine and urine examination. Despite treatment with oral potassium chloride plus a high potassium diet, his serum potassium fell to 2.3 mmol/1 4 days later, accompanied by inappropriate kaliuresis, hypouricemia with inappropriate uri-cosuria, and hypophosphatemia with inappropriate phosphaturia. There was no bicarbonate wasting, but there was proteinuria 1.2 g/day, with a predominance of low molecular weight proteins in contrast, serum creatinine was normal and creatinine clearance was 78 ml/minute. The aminoglycoside was withdrawn with subsequent progressive improvement in renal proximal tubular function, which normalized 9 days later. 

Hoffman RJ, Hoffman RS, Freyberg CL, Poppenga RH, Nelson LS. Clenbuterol ingestion causing prolonged tachycardia, hypokalemia, and hypophosphatemia with confirmation by quantitative levels. J Toxicol Clin Toxicol 2001 39(4) 339-44. 

Severe hypophosphatemia with myocardial dysfunction was noted in patients receiving tumor necrosis factor alfa by continuous hepatic arterial infusion (SEDA-17, 433). 

X-linked genetic hypophosphatemia with rickets (20) Methemoglobin reductase deficiency (21)... 

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