Hypertension sorbitol

Blood Pressure Lowering. The hypertensive effect of several expl compds has been reported by Salle (Refs 1,2, 3). Dinitroglycerol, NGc, bis(hydroxy-methyl)nitroethane dinitrate, dimethylol nitroethane dinitrate, bis(hydroxymethyl)nirropropane dinitrate dimethylol nitropropane dinitrate were studied. These compds were found to be vasodilators, less active than NG but excercising a more lasting effect(Ref 3). Nitrated sorbitol has a vasodilator effect similar to hexanitromannitol(HNMnt) but is si more toxic than HNMnt(Ref 2)... 

Vitamin C is also able to protect the hypothalamus from oxidative stress induced in rats by an environmental toxicant (Muthuvel et al., 2006). Ascorbic acid confers protection from increased free-radical activity in the brain of spontaneously hypertensive rats by improving total antioxidant and superoxide dismutase status, thus preventing high blood pressure and its complications (Newaz et al., 2005). Also, intravenous cerebroprotective doses of citrate/sorbitol-stabilized DHA are correlated with increased brain ascorbate levels and a suppression of excessive lipid peroxidation (Mack et al., 2006). 

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