Hypertension drug interactions

Table 24.2 Antihypertensive + Anti hypertensive drug interactions...

Chronic use of these irreversible MAO inhibitors has been associated with life-threatening toxicity, ie, hepatotoxicity and hypertensive crisis. Interactions with tyramine contained in food and other drugs have severely limited use of irreversible MAO inhibitors. These MAO inhibitors are also nonselective, inhibiting both MAO-A and MAO-B isoenzymes. Furthermore, they interfere with the hepatic metabolism of many dmgs. 

The use of duloxetine in stress urinary incontinence is complicated by (1) the potential for multiple clinically relevant drug-drug interactions with cytochrome P-450 2D6 and 1A2 inhibitors, (2) withdrawal reactions if abruptly discontinued, (3) high rates of nausea and other side effects, (4) the hepa-totoxicity that contraindicates its use in patients with any degree of hepatic impairment, and (5) its mild hypertensive effect. 

Tricyclic antidepressants are notorious for their risk to be involved in drug-drug interactions. Additive anticholinergic effects can be expected in combination with antihistamines, antipsychotics and anticholinergic-type anti-Parkinson agents. Hepatic enzyme-inducing agents increase their hepatic metabolism while enzyme inhibitors may potentiate the effects of tricyclics. Concomitant use with monoamine oxidase inhibitors will produce hypertension, hyperpyrexia and convulsions. 

Drug-drug interactions Hypertensive crisis with dietetic transgression or with certain drugs Weight gain Drowsiness... 

Drug interactions Co-administration of dinoprostone in patients receiving intravenous oxytocic agents such as oxytocin may result in uterine hyperstimulation and is therefore contraindicated. Severe hypertension has been reported when oxytocin was given 3 to 4 hours following prophylactic administration of a vasoconstrictor in conjunction with spinal anesthesia. Oxytocin may enhance the neuromuscular blockade of succinylcholine. 

The serotonin syndrome and hypertensive crisis are the two most common serious pharmacodynamically mediated drug-drug interactions are discussed in the following paragraphs. 

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