3- Hydroxypropionic acid glycerol metabolism

Jung, W.S., Kang, J.H., Chu, H.S., Choi, I.S., Cho, K.M., 2014. Elevated production of 3-hydroxypropionic acid by metabolic engineering of the glycerol metabolism in Escherichia coli. Metabolic Engineering 23,116-122. 

K. et al. (2014) Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli. Microb. Cell Fact, 13, 64. 

Ashok S, Raj SM, Ko Y, Sankaranarayanan M, Zhou S, Kumar V, Park S. (2013b). Effect of nitrate on glycerol metabolism and anaerobic production of 3-hydroxypropionic acid by recombinant Klebsiella pneumoniae overexpressing puuC. Metab Eng, 15,10-24. 

Ashok S, Mohan Raj S, Ko Y, et al. Effect of puuC overexpression and nitrate addition on glycerol metabolism and anaerobic 3-hydroxypropionic acid production in recombinant Klebsiella pneumoniae AglpK AdhaT. Metab Eng 2013 15 10-24. 

Figure 11.7. Metabolic formation of 1,3-propanediol and 3-hydroxypropionic acid from glycerol through the Intermediate 3-hydroxypropionaldehyde (3-HPA) by some lactic acid bacteria. Acrolein is formed through a chemical dehydration of 3-HPA. Adapted from Sobolov and Smiley (1960), Sllnlnger et al. (1983), and Schiitz and Radler (1984).

Kim, K., Kim, S.K., Park, Y.C., and Seo, J.H. (2014) Enhanced production of 3-hydroxypropionic acid from glycerol by modulation of glycerol metabolism in recombinant Escherichia coli. Bioresour. TechnoL, 156,... 

Tokuyama, K., Ohno, S., Yoshikawa, K., Hirasawa, T., Tanaka, S., Furusawa, C., and Shimizu, H. (2014) Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli. Microb. Cell Fact., 13, 64. 

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