Hydroxyapatite/chitosan nanoparticles

Hydroxyapatite (HA) nanoparticles are osteoconductive bioactive ceramics that can support bone cell adhesion and proliferation and accelerate bone defects healing. HA is typically added to polymeric nanofibers to increase their mechanical strength. HA, often in the form of needle-like nanoparticles, was electrospun in the presence of synthetic biocompatible and biodegradable polymers such as PLA [5, 58-60] and PLA-PEG-PLA [61], natural polymers such as chitosan [62] and collagen [63, 64], and blends of natural and synthetic polymers such as PVA/chitosan [65] and PCL/gelatin [66]. 

Tavakol, S., Nikpour, M., Amani, A., et al., 2013. Bone regeneration based on nano-hydroxyapatite and hydroxyapatite/chitosan nanocomposites an in vitro and in vivo comparative study. Journal of Nanoparticle Research 15 (1), 1-16. 

Scanning electron micrograph of a [Chi(HAP)/PAA]2 bilayer film with the hydroxyapatite nanoparticles, which are interwoven in the multilayer architecture and complexed to chitosan (g) IR absorbance spectra of the different components of the osteoconductive layer (i) chitosan, (ii) hydroxyapatite, (iii) poly(acrylic acid), (iv) [Chitosan/HAP]j, (v) [Chitosan/ PAA]j , and (vi) [Chi(HAP)/PAA] . 

Shen K, Hu Q, Chen L, Shen J (2010) Preparation of chitosan bicomponent nanofibers filled with hydroxyapatite nanoparticles via electrospinning. J Appl Polym Sci 115 2683-2690... 

Gao, C., et al., 2013. Development and characterization of injectable chitosan-based hydrogels containing dexamethasone/rhBMP-2 loaded hydroxyapatite nanoparticles. Mater. Lett. 93, 312-315. http //dx.doi.Org/10.1016/j.matlet.2012.ll.106. 

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