Hydroxyapatite biomimetic

Kim, H.-W., J.-H. Song, and H.-E. Kim (2005). Nanoliber generation of gelatin-hydroxyapatite biomimetics for guided tissue regeneration. Advanced... 

One of the important fields where carbohydrate polymer/inorganic hybrids may be successfully applied is bioactive materials, e.g., artificial bones expedient for surgery to accelerate the recovery of living bones. There has been increasing interest in hydroxyapatite (HAp) deposition onto the matrix surface of cellulose or related polysaccharide. HAp is a form of calcium phosphate, a main constituent of the inorganic phase of human bone. This kind of study is also a step on the way to exploitation of new biomimetic mineralization methods. 

Tanaka, T., Hirose, M., Kotobuki, N., Ohgushi, H., Furuzono, T., and Sato, J. "Nano-scaled hydroxyapatite/silk fibroin sheets support osteogenic differentiation of rat bone marrow mesenchymal cells". Mater. Sci. Eng. C Biomimetic Supramol. Sys. 27(4), 817-823 (2007). 

Ethirajan A, Ziener U, Chuvilin A, Kaiser U, Colfen H, Landfester K (2008) Biomimetic hydroxyapatite crystallization in gelatin nanoparticles synthesized via miniemulsion process. Adv Funct Mater 18(15) 2221-2227... 

Ethirajan A, Ziener U, Landfester K (2009) Surface-functionalized polymeric nanoparticles as templates for biomimetic mineralization of hydroxyapatite. Chem Mater 21(11) 2218-2225... 

Kikuchi, M. Ikoma, T. Itoh, S. Matsumoto, H.N. Koyama, Y. Takakuda, K. Shinomiya, K. Tanaka, J. Biomimetic synthesis of bone-like nanocomposites using the self-organization mechanism of hydroxyapatite and collagen. Composites Sciences and Technology 2004, 64, 819-825. 

Keywords Biomimetic Bone Electrospinning Growth factors Hydroxyapatite Nanofibers... 

Forsgren, J. et al.. Formation and adhesion of biomimetic hydroxyapatite deposited on titanium substrates, Acta Biomater., 3, 980, 2007. 

Xie, J. and Luan, B.L.. Eormation of hydroxyapatite coating using novel chemo-biomimetic method.. 1. Mater. Sci. Mater. Med.. 19. 3211, 2008. 

Proteins such as rhBMP can be incorporated into calcium phosphate layers when biomimetically co-precipitated with the inorganic components (Liu et al., 2004). For example, rhBMP-2 (0.1-10pgml-1) retains its osseoinductive potential when incorporated into the crystal lattice of hydroxyapatite in a dose-dependent manner as ascertained by protein blot staining and enzyme-linked immunosorbent assay (ELISA). The positive osseogenicity of rhBMP-2 was assessed quantitatively by monitoring ALP activity (see Section 7.10.3.1) on rat BMSCs grown directly on the calcium phosphate coatings. 

H.Y. (2006) Carbon nanotubes assisted biomimetic synthesis of hydroxyapatite from simulated body fluid. Mater. Sci. Eng. A, 426, 202-207. 

A supersaturated bioinspired solution was used to coat alumina and zirconia substrates with a thin, poorly crystalline layer of OCP that after heat treatment at 1050 °C for 1 h was converted to hydroxyapatite with particle size of 300 nm (Pribosic, Beranic-Klopcic and Kosmac, 2010). Stefanic et al. (2012) applied a related method to rapidly deposit an OCP layer by a two-step process onto yttria-stabilised tetragonal zirconia polycrystal (Y-TZP). 80vol% Mg-PSZ/20 vol% alumina substrates were used by Nogiwa and Cortes (2006) to deposit biomimetically by immersion in 1.4 SBF a bone-like apatite coating of 15-30 pm thickness, using a bed of either wollastonite ceramics or bioactive glass as an additional source of Ca2+ ions. 

Biomimetic hydroxyapatite deposition routes were investigated on titanium oxide surfaces (Xia etal., 2011), silicon nitride (Chaves Guedes e Silva etal., 2008), wollastonite (Huang, Jiang and Tan, 2004), canasite (Ca5Na3K3Si12O30(OH,F)4) glass ceramic (Miller etal., 2002) and also pyrolytic carbon and carbon-carbon composite (CCC) ceramics (Hoppe etal., 2013). 

Biomimetic coating of cholesterol with hydroxyapatite is characterised by an epitaxial relationship between cholesterol monohydrate recrystallised from polar solvents and hydroxyapatite, and thus enhances deposition rate. However, chemical modification of cholesterol, for example by phosphorylation destroys the epitaxy and hence this material fails to act as a viable template for calcium phosphate deposition (Laird, Mucalo and Yokogawa, 2006). This research may... 

Bharati, S., Sinha, M.K., and Basu, D. (2005) Hydroxyapatite coating by biomimetic method on titanium alloy using concentrated SBF. Bull. Mater. Sci., 28 (6), 617-621. 

L. (2005) Nanocrystalline hydroxyapatite coatings on titanium a new fast biomimetic method. Biomaterials, 26 (19), 4085 -4089. 

A.H., and Bressiani, J.C. (2008) Hydroxyapatite coating on silicon nitride surfaces using the biomimetic method. Mater. Res., 11 (1), 47-50. 

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