4-hydroxy-8-methyl-3,4-dihydro

H-Azepinium perchlorate, 6,7-dihydro-formation, 7, 512 Azepinoindoles synthesis, 7, 537 Azepin-2-one, hexahydro-chlorination, 7, 517 synthesis, 7, 530 Azepin-2-one, 3-hydroxy-methylation, 7, 518... 

Indazole, 5,5-dimethyl-3-trifluoromethyl-4,5-dihydro-trichomonacidal activity, 5, 291 Indazole, 2-ethoxycarbonyl-reactions, 5, 269 Indazole, 3-fluoro-synthesis, S, 263 Indazole, 1-germyl-synthesis, 5, 236 Indazole, 1-glycosyl-synthesis, 5, 289 Indazole, 2-glycosyl-synthesis, 5, 289 Indazole, halo-reactions, S, 266 Indazole, 2-hydroxy-methylation, 5, 269 Indazole, 3-hydroxy-reactions, S, 264 Indazole, 6-hydroxy-diazo coupling, 5, 86 Indazole, hydroxyphenyl-synthesis, S, 288 Indazole, 3-iodo-synthesis, S, 241 Indazole, l-isopropyl-3-phenyl-reduction, 5, 243 Indazole, 3-mercapto-1 -substituted tautomerism, 5, 265 Indazole, methoxy-... 

Pyran-2-one, 5,6-dibromo-5,6-dihydro-reactions, 3, 735 Pyran-2-one, 5,6-dihydro-allylic bromination, 3, 799 dehydrogenation, 3, 724, 799 H NMR,3, 581 synthesis, 3, 841, 843 Pyran-2-one, 4,6-dimethyl-irradiation, 3, 677 photochemistry, 3, 678 Pyran-2-one, 5,6-dimethyl-chloromethylation, 3, 680 conformation, 3, 631 Pyran-2-one, 5-f ormyl-IR Spectra, 3, 595 Pyran-2-one, 6-formyl-IR spectra, 3, 595 Pyran-2-one, 5-halo-synthesis, 3, 799 Pyran-2-one, 3-hydroxy-IR spectra, 3, 595 Pyran-2-one, 4-hydroxy-methylation, 2, 57 3, 676 pyran-4-one synthesis from, 3, 816 reactions with phosphorus oxychloride, 2, 57 synthesis, 3, 792, 794, 795, 798 tautomerism, 2, 56 3, 642 Pyran-2-one, 4-hydroxy-6-methyl-methylation, 3, 692 reactions... 

Treatment of alkyl 9-benzyloxycarbonyl-3-methyl-6-oxo-2/7,6//-pyr-ido[2,l-f ][l,3]thiazine-4-carboxylates with BBr3 in CH2CI2 at -70 °C for 0.5-1 h and at room temperature for 3h yielded 9-carboxyl derivatives. The decarboxylation of these acids was unsuccessful. Hydrolysis of diethyl cA-3,4-H-3,4-dihydro-3-methyl-6-oxo-2//,6//-pyrido[2,l-f ][l,3]thiazine-4,9-dicarboxylate in aqueous EtOH with KOH at room temperature for 3 days yielded 4-ethoxycarbonyl-3,4-dihydro-3-methyl-6-oxo-2//,6//-pyrido-[2,l-f ] [1,3]thiazine-9-carboxylic acid (00JCS(P1)4373). Alkyl 9-hydroxy-methyl-3-methyl-6-oxo-3,4-dihydro-2//,6//-pyrido[2,l-f ][l,3]thiazine-4-car-boxylates were O-acylated with AC2O and (PhC0)20 in pyridine at room temperature for 12-48h. 

Dimethylquinoxaline (147) gave 2-ethoxycarbonyl-2-hydroxy -methyl-2,3-dihydro-[l/ ]-pyrrolo[l,2-u]quinoxalin-10-ium bromide (148) (BrCH2CO-C02Et, AcEt, reflux, 3h, then 20°C, 12 h 72%) and thence successively ethyl 4-methylpyrrolo[l,2-fl]quinoxaline-2-carboxylate (149) (EtONa, EtOH, 20°C, 4h 93% note oxidation by loss of H2O), the uncharacterized quaternary salt (150) (as the first step but 6h 50%), and diethyl dipyr-rolo[l,2-fl 2, l -c]quinoxaline-2,ll-dicarboxylate (151) (KOH, H2O, reflux, 1 h 56%). ° " - ... 

This enzyme [EC 2.7.6.3], also known as 6-hydroxy-methyl-7,8-dihydropterin pyrophosphokinase and 7,8-dihydro - 6 - hydroxymethylpterin pyrophosphokinase, catalyzes the reaction of ATP with 2-ammo-4-hydroxy-... 

R,4R)1-Cyclooctylmethyl-3-hydroxy-methyl-piperidin-4-yl]-3-ethyl-1,3-dihydro-benzoi-midazol-2-one, C24H37N3O2, Mr 399.57... 

DIHYDRO-11-BRONO-14-HYDROXY-. METHYL ESTER. (3-alpha. 14-beta, 16-alpha)-. (Et-2-BUTENEDIOATE (Kll (SALT)... 

Llebaria A, van Echten-Deckert G. Specificity of the dihydro- 163. ceramide desaturase inhibitor N-((lR,2S)-2-hydroxy-1-hydroxy methyl-2-(2-tridecyl-l-cyclopropenyl)ethyl)octanamide (GTl 1)... 

Nortestosterone. 1 -Methyl-A -3-desoxo-5a-dihydro 17-acetate (N-64), la-methyl 5a-dihydro (N-48), la-methyl 5a-dihydro 17-acetate (N-61), la-hydroxy 5a-dihydro 17-acetate (N-62), la,2a-methylene 5a-dihydro 17-acetate (N-63), and la-methyl-A -5a-dihydro 17-acetate (N-65) substitutions all markedly decrease the androgenic activity while the anabolic activity is decreased in a smaller degree. The anabolic-androgenic ratio becomes favorable. 

The reaction of 1,3-disubstituted perhydropyrido[l,2-c][l,3]oxazines (69) and 7-(benzothiazol-l-yl)-6,7-dihydro-17/,3//,5//-pyrido[3,2,l-iy][3,l]benz-oxazine with Grignard reagents led to 2-(/V-substituted 2-piperidyl)ethanols (70) (50JA358 58CLY2081) and l-benzyl-4-(benzotriazol-l-yl)-8-hydroxy-methyl-l,2,3,4-tetrahydroquinoline (95JOC3993), respectively. 

Dimethyl-2,3-dihydro-l,3-thiazol-2-yl-methyl)-4-methyl- 315 2- [(l R )-D-2,2-Dimcthyl-l, 3-dioxolan-4-yl]-hydroxy-methyl -... 

An analogous rearrangement was observed with the preparation of l-benzyl-4,9-dihydro-4,6-dimethyl-7-(3-methyl-l -butenyl)-l //-imidazo[l, 2-a]purin-9-one (185a) by a three-step synthesis from 1-benzyl-4,9-dihydro-4,6-dimethyl-7-(hydroxy-methyl)-l//-imidazo[l,2-a]purin-9-one (183), which reacted with phosphorus tribromide to the corresponding 7-bromomethyl derivative 184a and with triphenylphosphine to the triphenylphosphonium bromide 184b. The latter reacted... 

Fusarubin. 374-Dihydro-3,6,9-trihydroxy-7-nietti-oxy-i-metbyi-1 H-nophtho 2,3-cjpyran-5,10-diune 5,8-di-h ydroxy-2-hydroxy-methyl)-6-methoxy-l, 4-naphthoquinone oxyjavanicin. C HmO, mol wt 306.26. C 58.82%, H 4.61%, O 36.57%. 1 solti from Fusarium solani Ruelius, Gauhe, Ann. 569, 38 (]950). Structure Hardegger et al. Helv. Chim. Acta 47, 2027 (1964). Efficient total synthesis Y, Tanoue ei al. Bull Chem. Soc. 60, 2927 (1987). 

H-Pyran-2-one, 5,6-dihydro-4-hydroxy-2H-Pyran-2-one, hydroxy-methyl- 3746, 3747 3430 ... 

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