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Enhancement of Binding Strength through Additional Hydrophobic Substituents

Enhancement of Binding Strength through Additional Hydrophobic Substituents [Pg.387]

The attachment of hydrophobic groups to selectin-binding scaffolds is an important approach to candidate inhibitors with increased potency and improved pharmaceutical properties. This strategy has been implemented by a number of authors in the following, three selected examples arc presented. [Pg.387]



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Binding additivity

Binding strength

Enhanced binding strength

Hydrophobic binding

Hydrophobic substituent

Strength Additives

Strength of binding

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