Hydrolysis of carboxylic acid derivatives

Transesterification and Hydrolysis of Carboxylic Acid Derivatives, Alcohols, and Epoxides... 

Cycloamylose-induced rate accelerations are by no means limited only to the hydrolysis of carboxylic acid derivatives. Indeed, one of the first ob-... 

Before discussmg the mechanism of cleavage of carboxylic acid esters and amides by hydrolases, some chemical principles are worth recalling. The chemical hydrolysis of carboxylic acid derivatives can be catalyzed by acid or base, and, in both cases, the mechanisms involve addition-elimination via a tetrahedral intermediate. A general scheme of ester and amide hydrolysis is presented in Fig. 3. / the chemical mechanisms of ester hydrolysis will be... 

This chapter deals with the kinetics and mechanisms of the hydrolysis of carboxylic acid derivatives of general formula RCOX. These include carboxylic acid halides, amides, and anhydrides with small sections on carboxylic acid cyanides etc. Many recent developments in this field have been made with acid derivatives in which R is not an aliphatic or aromatic group, for example, carbamic acid derivatives, and these are reported where relevant, as are reactions such as ethanolysis, aminolysis, etc. where they throw light on the mechanisms of hydrolysis. 

Various aspects of the hydrolysis of carboxylic acid derivatives have been reviewed by Bender1, Hudson2, Johnson3 and Bruice and Benkovic4. 

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