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Hydrogen bond amino acids

In these two Ni-functionalized CNT materials, the Ni-molecular catalyst is located at the crossroads of the three interpenetrated networks allowing percolation of protons (the Nafion membrane), hydrogen (the pores in the gas diffusion layer), and electrons (the carbon fibers of the gas diffusion layer relayed by the conducting CNTs). In a way and even if it is not as well defined as in the protein, the catalyst environment in this membrane-electrode assembly reproduces that found in the active sites of hydrogenases buried into the polypeptidic framework but connected to the surfece of the protein via a gas diffusion channel, a network of hydrogen-bonded amino acids for proton transport and the array of electrontransferring iron-sulfur clusters. [Pg.306]

The dynamic behavior of the model intermediate rhodium-phosphine 99, for the asymmetric hydrogenation of dimethyl itaconate by cationic rhodium complexes, has been studied by variable temperature NMR LSA [167]. The line shape analysis provides rates of exchange and activation parameters in favor of an intermo-lecular process, in agreement with the mechanism already described for bis(pho-sphinite) chelates by Brown and coworkers [168], These authors describe a dynamic behavior where two diastereoisomeric enamide complexes exchange via olefin dissociation, subsequent rotation about the N-C(olefinic) bond and recoordination. These studies provide insight into the electronic and steric factors that affect the activity and stereoselectivity for the asymmetric hydrogenation of amino acid precursors. [Pg.40]

Figure 2-2. Structures of a-helix and P-sheet Dashed lines indicate hydrogen bonds that stabilize these types of secondary structure. The hydrogen bonds of the a-helix are intrastrand, ie, formed between the backbone carbonyl oxygen and the amide hydrogen four amino acids up the helix. R groups represent the side chains in the a-helix. Side chains that would project above and below the plane of the page in the P-sheet structures have been omitted for clarity. Hydrogen bonds stabilizing the p-sheet are interstrand, ie, formed between groups on neighboring strands. Figure 2-2. Structures of a-helix and P-sheet Dashed lines indicate hydrogen bonds that stabilize these types of secondary structure. The hydrogen bonds of the a-helix are intrastrand, ie, formed between the backbone carbonyl oxygen and the amide hydrogen four amino acids up the helix. R groups represent the side chains in the a-helix. Side chains that would project above and below the plane of the page in the P-sheet structures have been omitted for clarity. Hydrogen bonds stabilizing the p-sheet are interstrand, ie, formed between groups on neighboring strands.
Lasiodine-A (59) (33), though not a cyclic peptide, exhibits many of the structural features common to that class and could conceivably result from subsequent scission of a cyclic precursor (4). Spectral study identified an isopropylidene, a secondary hydroxyl, a phenolic hydroxyl, and an ester function. Mass spectra fail to reveal the molecular ion but a fragment of mass M-I06 as known from some other peptide alkaloids containing phenylserine as ring bond amino acid (30,31,62). Catalytic hydrogenation generates N-methylvaline and a moiety (83) whose structure was deduced from spectral studies and from hydrolytic degradations. Reduction of the alkaloid with lithiumaluminiumhydride... [Pg.187]

Further prominent examples for face selective reactivity (but for different reasons) are encountered with sulfanilic acid monohydrate 16 and 4-aminobenzoic acid 7. They do not diazotize on their (010) face with N02 or on the (001) face with NOC1, respectively, where molecules cannot exit due to infinite hydrogen-bonded strings. Conversely, at slopes on (010) of 16 or on (100) of 7, where the hydrogen-bonded amino groups of the strings are freely available, reaction occurs [18, 32, 33]. [Pg.104]

Every carbonyl oxygen is hydrogen-bonded to an amide hydrogen four amino acids away in the chain. [Pg.567]

Additional evidence was obtained for the structure (110) of the compound derived from D-mannose, ammonia, and ethyl acetoacetate. This substance, when suspended in water and kept at room temperature, is slowly hydrolyzed, giving di-n-mannosylamine, isolated in the crystalline state, and n-mannose, characterized as its phenylhydrazone. Acetylation gives a tetra-O-acetyl derivative (111). The infrared spectrum of this acetate shows bands at 3280 cm. , attributable to the presence of an intramolecularly bonded NH group, and at 1658 cm. S probably due to the carbonyl group of the /3-amino a, 8-unsaturated ester also involved in a hydrogen bond. Mild, acid hydrolysis of (111) gives 2,3,4,6-tetra-O-acetyl-D-mannose. [Pg.341]

The pH has a great influence on the ionisation of polar functional groups in the protein-bound amino acids, and thus on the abihty of proteins to interact with water (bind water). Ionised functional groups of proteins interact with water in a similar way to salt ions. The ionised basic side chains of lysine and histidine bind about four molecules of water by hydrogen bonds, the acidic side chains of glutamate and aspartate bind about six water molecules, while the neutral carboxyl groups of amino acids (interaction of dipole-dipole type) bind two water molecules of as well as the polar non-ionised side chains of serine and other amino acids. [Pg.482]

Racemases are enzymes that catalyze the inversion of the chiral center by deprotonation of the C , followed by reprotonation on the opposite face of the planar carban-ionic transition-state species [13,14], In order to overcome the high energetic barrier of racemization, for example, on a-amino acids, some racemases employ pyridoxal phosphate (PLP) as a cofactor to use the resonance-stabilized amino acid complex as an electron sink because the estimated pK values for the C of amino acids are high, in the range 21-32 [14,15]. The formation of an imine PLP-substrate covalent bond makes the pK value of a-hydrogen of amino acids low. The second class of enzymes includes proline, aspartate, and glutamate racemases and diaminopimelate epimer-ase, with a cofactor-independent two-base mechanism [14],... [Pg.492]


See other pages where Hydrogen bond amino acids is mentioned: [Pg.215]    [Pg.404]    [Pg.88]    [Pg.19]    [Pg.54]    [Pg.1306]    [Pg.19]    [Pg.170]    [Pg.23]    [Pg.138]    [Pg.70]    [Pg.621]    [Pg.66]    [Pg.7]    [Pg.3527]    [Pg.125]    [Pg.223]    [Pg.215]    [Pg.404]    [Pg.88]    [Pg.19]    [Pg.54]    [Pg.1306]    [Pg.19]    [Pg.170]    [Pg.23]    [Pg.138]    [Pg.70]    [Pg.621]    [Pg.66]    [Pg.7]    [Pg.3527]    [Pg.125]    [Pg.223]    [Pg.321]    [Pg.318]    [Pg.452]    [Pg.311]    [Pg.321]    [Pg.1132]    [Pg.127]    [Pg.678]    [Pg.1132]    [Pg.167]    [Pg.307]    [Pg.33]    [Pg.143]    [Pg.35]    [Pg.372]    [Pg.773]    [Pg.342]    [Pg.240]    [Pg.332]    [Pg.1515]    [Pg.2827]    [Pg.2834]    [Pg.46]   
See also in sourсe #XX -- [ Pg.407 , Pg.409 , Pg.415 , Pg.426 ]




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